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Paediatric supratentorial tumours do not cause microstructural alterations in contralateral white matter: a preliminary study

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Abstract

Background and purpose

Intracranial tumours in children can exhibit different characteristics compared to those in adults. Understanding the microstructural changes in the contralateral normal-appearing white matter (NAWM) in children with primary intracranial masses is essential for optimizing treatment strategies. This study aimed to investigate the apparent diffusion coefficient (ADC) changes in contralateral NAWM using fully automated methods and deep learning algorithms.

Methods

We included 22 paediatric patients with primary supratentorial intracranial masses (23% high-grade) in the study. ADC values of the contralateral NAWM in the patient group were compared to those of a control group. Deep learning algorithms were utilized to analyse diffusion changes in NAWM.

Results

The mean ADC values of contralateral NAWM in the patient group were 0.80 ± 0.03 × 10−3 mm2/s, while the control group had a mean ADC value of 0.81 ± 0.03 × 10−3 mm2/s. There was no statistically significant difference between the groups (p = 0.39). Our findings indicate that there are no significant diffusion changes in the contralateral white matter of children with supratentorial intracranial masses.

Conclusion

Primary supratentorial intracranial masses in children do not cause microstructural changes in contralateral normal-appearing white matter. This could be attributed to the less infiltrative nature and different biochemical profile of these tumour groups in the paediatric population. Further studies using advanced imaging techniques could provide additional insights into the distinct characteristics of paediatric intracranial tumours and improve patient management.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Radiology, Samsun Education and Research Hospital, İlkadım, Samsun, 55060, Turkey

    Barış Genç

  2. Department of Radiology, Amasya Sabuncuoğlu Şerefeddin Education and Research Hospital, Amasya, Turkey

    Semra Delibalta

  3. Department of Radiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey

    Kerim Aslan

  4. Department of Pediatric Radiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey

    Meltem Necibe Ceyhan Bilgici

Authors
  1. Barış Genç
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  2. Semra Delibalta
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  3. Kerim Aslan
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  4. Meltem Necibe Ceyhan Bilgici
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Contributions

Barış Genç: project development, data collection, data analysis and manuscript writing/editing. Semra Delibalta: project development and data collection. Kerim Aslan: data collection, data analysis and manuscript editing. Meltem Necibe Ceyhan Bilgici: project development, data collection and manuscript editing.

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Correspondence to Barış Genç.

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Genç, B., Delibalta, S., Aslan, K. et al. Paediatric supratentorial tumours do not cause microstructural alterations in contralateral white matter: a preliminary study. Childs Nerv Syst 40, 41–46 (2024). https://doi.org/10.1007/s00381-023-06083-z

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  • DOI: https://doi.org/10.1007/s00381-023-06083-z

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