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Heterogeneity of glioblastoma with gliomatosis cerebri growth pattern on diffusion and perfusion MRI

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Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Background and purpose

Gliomatosis cerebri (GC) is a rare growth pattern of glioblastoma whose diffuse nature is reflected by unspecific, relatively uniform findings on conventional MRI. In the present study we sought to evaluate the additional value of diffusion (DWI) and perfusion weighted (PWI) MRI for a more detailed characterization.

Methods

We analyzed the MRI findings in patients with histologically proven glioblastoma with GC growth pattern with a specific emphasis on T2 lesion pattern, volume, relative apparent diffusion coefficient (rACD), and relative cerebral blood volume (rCBV) and compared these to age-/gender-matched patients with localized glioblastoma.

Results

Overall, 16 patients (median age 59.5 years, 4 male) were included in the study. Of these, 8 patients had a glioblastoma with GC growth pattern, and 8 a classical localized growth pattern. While the median rADC (1.27 [IQR 1.12–1.41]) within the T2 lesion was significant lower in glioblastoma with GC growth pattern compared to localized glioblastoma (1.74 [IQR 1.45–1.96]; p = 0.003), the median T2 lesion volume and rCBV within the T2 lesion did not differ significantly. Furthermore, six patients with glioblastoma with GC growth pattern showed focal areas with significantly reduced rADC (p = 0.043), and/or increased rCBV (p = 0.028).

Conclusions

Lower rADC in glioblastoma with GC growth pattern might reflect the diffuse tumor cell infiltration whereas focal areas with decreased rADC and/or increased rCBV probably indicate high tumor cell density and/or abnormal tumor vessels which may be useful for biopsy guidance.

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Author information

Author notes

  1. Alex Förster and Stefanie Brehmer contributed equally to the manuscript.

Authors and Affiliations

  1. Department of Neuroradiology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany

    Alex Förster, Holger Wenz & Christoph Groden

  2. Department of Neurosurgery, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

    Stefanie Brehmer, Marcel Seiz-Rosenhagen & Daniel Hänggi

  3. Department of Neurology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

    Iris Mildenberger

  4. Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

    Frank A. Giordano

  5. Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany

    David Reuss

  6. Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    David Reuss

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  1. Alex Förster
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  2. Stefanie Brehmer
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Corresponding author

Correspondence to Alex Förster.

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Conflict of interest

Alex Förster: none. Stefanie Brehmer received travel support from Carl Zeiss Meditec AG. Marcel Seiz-Rosenhagen: none. Iris Mildenberger: none. Frank A. Giordano serves as consultant and speaker for Carl Zeiss Meditec AG, NOXXON Pharma AG, Merck Serono GmbH, Roche Pharma AG, Siemens Healthcare Diagnostics GmbH, and holds patents related with Carl Zeiss Meditec AG. Holger Wenz: none. David Reuss: none. Daniel Hänggi: none. Christoph Groden: none.

Ethical approval

This study has been approved by the local institutional review board (Medizinische Ethikkommission II der Medizinischen Fakultät Mannheim) and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Patient consent was waived for this analysis by the local institutional review board due to its retrospective nature.

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Förster, A., Brehmer, S., Seiz-Rosenhagen, M. et al. Heterogeneity of glioblastoma with gliomatosis cerebri growth pattern on diffusion and perfusion MRI. J Neurooncol 142, 103–109 (2019). https://doi.org/10.1007/s11060-018-03068-w

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  • DOI: https://doi.org/10.1007/s11060-018-03068-w

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