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Focal cortical dysplasia: etiology, epileptogenesis, classification, clinical presentation, imaging, and management

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Abstract

Background

Focal cortical dysplasia (FCD) is the most prevalent cause of intractable epilepsy in children. It was first described by Taylor et al. in 1971. In 2011, the International League against Epilepsy described an international consensus of classification for FCD. However, the exact mechanism causing this pathology remains unclear. The diagnosis and recognition of FCD increase with the advances in neuroradiology and electrophysiology.

Focus of review

In this paper, we discuss the literature regarding management of FCD with a focus on etiology, pathophysiology, classification, clinical presentation, and imaging modalities. We will also discuss certain variables affecting surgical outcome of patients with FCD.

Conclusion

Based on our review findings, it is concluded that surgical management with complete resection of the lesion following preoperative localization of the epileptogenic zone in patients with FCD subtypes can provide a seizure-free outcome.

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Acknowledgments

The authors thank Drs. Asli Cakir, Erim Cobanoglu and Gulhan Ertan Akan for their contributions to providing of histopathological and imaging figures.

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Authors and Affiliations

  1. Department of Neurosurgery, Istanbul Medipol University School of Medicine, Istanbul, Turkey

    Alican Tahta

  2. Department of Neurosurgery, Aydın Adnan Menderes University School of Medicine, Efeler, Aydın, Turkey

    Mehmet Turgut

  3. Department of Histology and Embryology, Aydın Adnan Menderes University Health Sciences Institute, Efeler, Aydın, Turkey

    Mehmet Turgut

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Tahta, A., Turgut, M. Focal cortical dysplasia: etiology, epileptogenesis, classification, clinical presentation, imaging, and management. Childs Nerv Syst 36, 2939–2947 (2020). https://doi.org/10.1007/s00381-020-04851-9

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