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Infected cephalohematomas and underlying osteomyelitis: a case-based review

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Abstract

Background

Cephalohematomas are relatively common sub-periosteal collections of blood that tend to resolve spontaneously without treatment. Rarely, they become infected and can be associated with underlying osteomyelitis, meningitis, or sepsis. Common pathogens include Escherichia coli and Staphylococcus species.

Illustrative case

This report describes the first case of a neonate developing an infected right parietal cephalohematoma and underlying osteomyelitis caused by Morganella morganii, which was cultured in blood and cephalohematoma aspirate. This infant male, whose risk factors included vacuum extraction during delivery and suspected post-natal pneumonia, responded well to a 6-week course of intravenous meropenem with complete resolution of both lesions.

Conclusion

When an infected cephalohematoma is suspected, aspiration of hematoma fluid should be performed for both diagnostic and therapeutic purposes. Infectious symptoms should warrant prompt investigation and treatment, which may include drainage, debridement, and antibiotics. This report demonstrates that the combination of an infected cephalohematoma and underlying osteomyelitis might not be as uncommon as previously believed.

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References

  1. Karagol BS, Zenciroglu A, Kundak AA, Okumus N, Aydin M, Uner C (2010) A linear fracture and meningitis associated with non-infected cephalohematoma in a neonate. Neuropediatrics 41:276–278

    Article  CAS  PubMed  Google Scholar 

  2. Broekhuizen FF, Washington JM, Johnson F, Hamilton PR (1987) Vacuum extraction versus forceps delivery: indications and complications, 1979 to 1984. Obstet Gynecol 69:338–342

    CAS  PubMed  Google Scholar 

  3. Dahl KM, Barry J, DeBiasi RL (2002) Escherichia hermannii infection of a cephalohematoma: case report, review of the literature, and description of a novel invasive pathogen. Clin Infect Dis Off Publ Infect Dis Soc Am 35:e96–e98

    Article  Google Scholar 

  4. Kao HC, Huang YC, Lin TY (1999) Infected cephalohematoma associated with sepsis and skull osteomyelitis: report of one case. Am J Perinatol 16:459–462

    Article  CAS  PubMed  Google Scholar 

  5. Ghali S, Knox KR, Boutros S, Thorne CH, McCarthy JG (2007) The incidence of late cephalohematoma following craniofacial surgery. Plast Reconstr Surg 120:1004–1008

    Article  CAS  PubMed  Google Scholar 

  6. Blom NA, Vreede WB (1993) Infected cephalhematomas associated with osteomyelitis, sepsis and meningitis. Pediatr Infect Dis J 12:1015–1017

    Article  CAS  PubMed  Google Scholar 

  7. Kersten CM, Moellering CM, Mato S (2008) Spontaneous drainage of neonatal cephalohematoma: a delayed complication of scalp abscess. Clin Pediatr 47:183–185

    Article  Google Scholar 

  8. Weiss KJ, Edwards MS, Hay LM, Allen CH (2009) Escherichia coli-infected cephalohematoma in an infant. Clin Pediatr 48:763–766

    Article  Google Scholar 

  9. Meigs JF, Pepper W (1877) A practical treatise on the diseases of children. Lindsay & Blakiston, Philadelphia

    Google Scholar 

  10. Goodwin MD, Persing JA, Duncan CC, Shin JH (2000) Spontaneously infected cephalohematoma: case report and review of the literature. J Craniofac Surg 11:371–375 discussion

    Article  CAS  PubMed  Google Scholar 

  11. Brook I (2005) Infected neonatal cephalohematomas caused by anaerobic bacteria. J Perinat Med 33:255–258

    Article  PubMed  Google Scholar 

  12. Chang HY, Chiu NC, Huang FY, Kao HA, Hsu CH, Hung HY (2005) Infected cephalohematoma of newborns: experience in a medical center in Taiwan. Pediatr Int Off J Japan Pediatr Soc 47:274–277

    Article  Google Scholar 

  13. Burry VF, Hellerstein S (1966) Septicemia and subperiosteal cepbalbematomas. J Pediatr 69:1133–1135

    Article  CAS  PubMed  Google Scholar 

  14. Cohen SM, Miller BW, Orris HW (1947) Meningitis complicating cephalhematoma. J Pediatr 30:327–329

    Article  CAS  PubMed  Google Scholar 

  15. Sjövall A (1936) Le céphalhématome des nouveau-nés. Acta Obstet Gynecol Scand 15:443–474

    Article  Google Scholar 

  16. Chan MC, Boon WH (1972) Infected cephalhaematoma. J Singapore Paediatr Soc 14:57–60

    CAS  PubMed  Google Scholar 

  17. Chen MH, Yang JC, Huang JS (2006) MRI features of an infected cephalhaematoma in a neonate. J Clin Neurosci Off J Neurosurg Soc Australas 13:849–852

    CAS  Google Scholar 

  18. Ellis SS, Montgomery JR, Wagner M, Hill RM (1974) Osteomyelitis complicating neonatal cephalhematoma. Am J Dis Child 127:100–102

    Article  CAS  PubMed  Google Scholar 

  19. Fan HC, Hua YM, Juan CJ, Fang YM, Cheng SN, Wang CC (2002) Infected cephalohematoma associated with sepsis and scalp cellulitis: a case report. J Microbiol Immunol Infect Wei mian yu gan ran za zhi 35:125–128

    PubMed  Google Scholar 

  20. Gordon HS, Aronow J (1955) Escherichia coli meningitis in five-day-old infant; report of a case with complete recovery. J Am Med Assoc 159:1288–1289

    Article  CAS  PubMed  Google Scholar 

  21. Handrick W, Huckel D, Spencker FB, Kuhnert C (1983) Infected scalp hematoma. Zentralblatt fur Gynakologie 105:1011–1013

    CAS  PubMed  Google Scholar 

  22. Hegde HR (1980) Infected cephalhematoma associated with placement of scalp electrode. Can Med Assoc J 122:876–878

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Huang CS, Cheng KJ, Huang CB (2002) Infected cephalohematoma complicated with meningitis: report of one case. Acta paediatr Taiwan Taiwan er ke yi xue hui za zhi 43:217–219

    PubMed  Google Scholar 

  24. Lee PY (1990) Infected cephalhaematoma and neonatal osteomyelitis. The Journal of infection 21:191–193

    Article  CAS  PubMed  Google Scholar 

  25. Levy HL, O’Connor JF, Ingall D (1967) Bacteremia, infected cephalhematoma, and osteomyelitis of the skull in a newborn. Am J Dis Child 114:649–651

    CAS  PubMed  Google Scholar 

  26. Meignier M, Renaud P, Robert R, Roze JC, Rigal E, Mouzard A (1989) Cephalhematoma infection in neonatal septicemia. Pediatrie 44:27–29

    CAS  PubMed  Google Scholar 

  27. Nakwan N, Wannaro J, Dissaneevate P, Kritsaneepaiboon S, Chokephaibulkit K (2011) Septicemia, meningitis, and skull osteomyelitis complicating infected cephalhematoma caused by ESBL-producing Escherichia coli. Southeast Asian J Trop Med Public health 42:148–151

    PubMed  Google Scholar 

  28. Tan KL (1972) Infected cephalhaematoma. Aust Paediatr J 8:107–110

    CAS  PubMed  Google Scholar 

  29. Wong CS, Cheah FC (2012) Cephalhematoma infected by Escherichia coli presenting as an extensive scalp abscess. J Pediatr Surg 47:2336–2340

    Article  PubMed  Google Scholar 

  30. Fleming H (1925) Osteomyelitis of the skull. Calif West Med 23:985–988

    CAS  Google Scholar 

  31. Overturf GD, Balfour G (1975) Osteomyelitis and sepsis: severe complications of fetal monitoring. Pediatrics 55:244–247

    CAS  PubMed  Google Scholar 

  32. Lee Y, Berg RB (1971) Cephalhematoma infected with Bacteroides. Am J Dis Child 121:77–78

    CAS  PubMed  Google Scholar 

  33. Listinsky JL, Wood BP, Ekholm SE (1986) Parietal osteomyelitis and epidural abscess: a delayed complication of fetal monitoring. Pediatr Radiol 16:150–151

    Article  CAS  PubMed  Google Scholar 

  34. Diwan N, Sharma KB (1978) Isolation of Salmonella typhimurium from cephalhematoma and osteomyelitis. Indian J Med Res 67:27–29

    CAS  PubMed  Google Scholar 

  35. Falagas ME, Kavvadia PK, Mantadakis E, Kofteridis DP, Bliziotis IA, Saloustros E, Maraki S, Samonis G (2006) Morganella morganii infections in a general tertiary hospital. Infection 34:315–321

    Article  CAS  PubMed  Google Scholar 

  36. McDermott C, Mylotte JM (1984) Morganella morganii: epidemiology of bacteremic disease. Infect Control: IC 5:131–137

    CAS  PubMed  Google Scholar 

  37. Lee IK, Liu JW (2006) Clinical characteristics and risk factors for mortality in Morganella morganii bacteremia. J Microbiol Immunol Infect Wei mian yu gan ran za zhi 39:328–334

    PubMed  Google Scholar 

  38. Koyuncu S, Ozan F (2012) Morganella morganii osteomyelitis complicated by secondary septic knee arthritis: a case report. Acta Orthop Traumatol Turc 46:464–467

    Article  PubMed  Google Scholar 

  39. Smithson Amat A, Perello Carbonell R, Arenillas Rocha L, Soriano Viladomiu A (2004) [Osteomyelitis of the rib due to Morganella morganii]. An Med Interna 21:464

    CAS  PubMed  Google Scholar 

  40. Miedema CJ, Ruige M, Kimpen JL (1999) Primarily infected cephalhematoma and osteomyelitis in a newborn. Eur J Med Res 4:8–10

    CAS  PubMed  Google Scholar 

  41. Mohon RT, Mehalic TF, Grimes CK, Philip AG (1986) Infected cephalhematoma and neonatal osteomyelitis of the skull. Pediatr Infect Dis 5:253–256

    Article  CAS  PubMed  Google Scholar 

  42. Nightingale LM, Eaton CB, Fruehan AE, Waldman JB, Clark WB, Lepow ML (1986) Cephalhematoma complicated by osteomyelitis presumed due to Gardnerella vaginalis. JAMA 256:1936–1937

    Article  CAS  PubMed  Google Scholar 

  43. Van Helleputte C, Dupont V, Barthels S, Aeby A (2010) Escherichia coli meningitis and parietal osteomyelitis in an infant: a rare complication of cephalohematoma. Revue medicale de Bruxelles 31:57–59

    PubMed  Google Scholar 

  44. Milligan KL, Barenkamp SJ (2013) Neonatal meningitis due to Morganella morganii. Clin Pediatr 52:462–464

    Article  Google Scholar 

  45. Sinha AK, Kempley ST, Price E, Sharma BK, Livermore DM (2006) Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production. Pediatr Infect Dis J 25:376–377

    Article  PubMed  Google Scholar 

  46. Verboon-Maciolek M, Vandertop WP, Peters AC, Roord JJ, Geelen SP (1995) Neonatal brain abscess caused by Morganella morgagni. Clin Infect Dis Off Publ Infect Dis Soc Am 20:471

    Article  CAS  Google Scholar 

  47. Ndiaye M, Sene MS, Sow AD, Seck LB, Coulibaly T, Diagne NS, Toure K, Diop AG, Ndiaye MM (2010) Meningoencephalitis due to Morganella morganii: a case report. Bull Soc Pathol Exot 103:230–232

    Article  CAS  PubMed  Google Scholar 

  48. Chang HY, Wang SM, Chiu NC, Chung HY, Wang HK (2011) Neonatal Morganella morganii sepsis: a case report and review of the literature. Pediatr Int Off J Japan Pediatric Soc 53:121–123

    Article  Google Scholar 

  49. Ovalle A, Martinez MA, Kakarieka E, Garcia M, Salinas A (2009) Fatal neonatal sepsis caused by vertical transmission of Morganella morganii. Report of one case. Revista medica de Chile 137:1201–1204

    PubMed  Google Scholar 

  50. Dutta S, Narang A (2004) Early onset neonatal sepsis due to Morganella morganii. Indian Pediatr 41:1155–1157

    PubMed  Google Scholar 

  51. Boussemart T, Piet-Duroux S, Manouana M, Azi M, Perez JM, Port-Lis M (2004) Morganella morganii and early-onset neonatal infection. Arch pediatr organe officiel de la Societe francaise de pediatrie 11:37–39

    CAS  Google Scholar 

  52. Casanova-Roman M, Sanchez-Porto A, Casanova-Bellido M (2002) Early-onset neonatal sepsis caused by vertical transmission of Morganella morganii. Scand J Infect Dis 34:534–535

    Article  PubMed  Google Scholar 

  53. Ranu SS, Valencia GB, Piecuch S (1999) Fatal early onset infection in an extremely low birth weight infant due to Morganella morganii. J Perinatol Off J Calif Perinatal Assoc 19:533–535

    Article  CAS  Google Scholar 

  54. Salen PN, Eppes S (1997) Morganella morganii: a newly reported, rare cause of neonatal sepsis. Acad Emerg Med Off J Soc Acad Emerg Med 4:711–714

    Article  CAS  Google Scholar 

  55. Rowen JL, Lopez SM (1998) Morganella morganii early onset sepsis. Pediatr Infect Dis J 17:1176–1177

    Article  CAS  PubMed  Google Scholar 

  56. Wan KS, Liu CK, Chen LH (2007) Primary urinary tract infection in infants: prophylaxis for uncomplicated pyelonephritis. Nephrol (Carlton) 12:178–181

    Article  Google Scholar 

  57. Okike IO, Johnson AP, Henderson KL, Blackburn RM, Muller-Pebody B, Ladhani SN, Anthony M, Ninis N, Heath PT (2014) Incidence, etiology, and outcome of bacterial meningitis in infants aged <90 days in the United Kingdom and Republic of Ireland: prospective, enhanced, national population-based surveillance. Clin Infect Dis Off Publ Infect Dis Soc Am 59:e150–e157

    Article  Google Scholar 

  58. LeBlanc CM, Allen UD, Ventureyra E (1995) Cephalhematomas revisited. When should a diagnostic tap be performed? Clin Pediatr 34:86–89

    Article  CAS  Google Scholar 

  59. Sonnen GM, Henry NK (1996) Pediatric bone and joint infections. Diagnosis and antimicrobial management. Pediatr Clin North Am 43:933–947

    Article  CAS  PubMed  Google Scholar 

  60. Kaufman HH, Hochberg J, Anderson RP, Schochet SS Jr., Simmons GM Jr. (1993) Treatment of calcified cephalohematoma. Neurosurgery 32:1037–1039 discussion 1039-1040

    Article  CAS  PubMed  Google Scholar 

  61. Martinez-Lage JF, Esteban JA, Martinez Perez M, Poza M (1984) Craniostenosis secondary to calcified subperiosteal hematoma: case report. Neurosurgery 15:703–704

    Article  CAS  PubMed  Google Scholar 

  62. Wong CH, Foo CL, Seow WT (2006) Calcified cephalohematoma: classification, indications for surgery and techniques. J Craniofac Surg 17:970–979

    Article  PubMed  Google Scholar 

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Correspondence to Michael D. Staudt.

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Staudt, M.D., Etarsky, D. & Ranger, A. Infected cephalohematomas and underlying osteomyelitis: a case-based review. Childs Nerv Syst 32, 1363–1369 (2016). https://doi.org/10.1007/s00381-016-3084-4

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