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Giant cranial and cerebellar hemangioma treated with propranolol

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Abstract

Introduction

Infantile hemangiomas are the most common benign tumors in children. However, cranial involvement of such lesions is rare. Current treatment options for hemangiomas in various locations that would be endangering or disfiguring include follow-up, surgical removal, or administration of corticosteroids, interferon-α, thalidomide, vincristine, propranolol, and laser therapy.

Methods

We describe an infant who presented with an extensive cranial hemangioma (proven by a biopsy). The child was treated with propranolol.

Results

Clinical and radiological follow-up for over a year showed significant reduction in tumor size without adverse clinical symptoms.

Conclusion

Propranolol is a valid treatment for large cranial hemangiomas, avoiding the risks involved in surgeries.

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References

  1. Ahrens WA, Ridenour Iii RV, Caron BL, Miller DV, Folpe AL (2008) GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasms. Hum Pathol 39(10):1519–1526. doi:10.1016/j.humpath.2008.03.002

    Article  CAS  PubMed  Google Scholar 

  2. Benesch M, von Bueren AO, Dantonello T, von Hoff K, Pietsch T, Leuschner I, Claviez A, Bierbach U, Kropshofer G, Korinthenberg R, Graf N, Suttorp M, Kortmann RD, Friedrich C, von der Weid N, Kaatsch P, Klingebiel T, Koscielniak E, Rutkowski S (2013) Primary intracranial soft tissue sarcoma in children and adolescents: a cooperative analysis of the European CWS and HIT study groups. J Neurooncol 111(3):337–345. doi:10.1007/s11060-012-1020-3

    Article  PubMed  Google Scholar 

  3. Bisogno G, Roganovic J, Carli M, Scarzello G, Calderone M, Faggin R, Perilongo G (2002) Primary intracranial fibrosarcoma. Childs Nerv Syst 18(11):648–651. doi:10.1007/s00381-002-0628-6

    Article  PubMed  Google Scholar 

  4. Chisholm KM, Chang KW, Truong MT, Kwok S, West RB, Heerema-McKenney AE (2012) β-Adrenergic receptor expression in vascular tumors. Mod Pathol 25(11):1446–1451. doi:10.1038/modpathol.2012.108

    Article  CAS  PubMed  Google Scholar 

  5. Jalloh I, Dean AF, O’Donovan DG, Cross J, Garnett MR, Santarius T (2014) Giant intracranial hemangioma in a neonate. Acta Neurochir 156(6):1151–1154. doi:10.1007/s00701-014-2007-y

    Article  PubMed  Google Scholar 

  6. Jong Gon Lee SWS, Koh Y-C, Cho J, Choi JW, Roh HG, Lim S-D (2013) Primary intracranial fibrosarcoma presenting with hemorrhage. Brain Tumor Res Treat 1:91–94

    Article  PubMed Central  PubMed  Google Scholar 

  7. Léauté-Labrèze C, de la Roque ED, Hubiche T, Boralevi F, Thambo J-B, Taïeb A (2008) Propranolol for severe hemangiomas of infancy. N Engl J Med 358(24):2649–2651. doi:10.1056/NEJMc0708819

    Article  PubMed  Google Scholar 

  8. Mirza B, Shi WY, Phadke R, Holton JL, Turner C, Plant GT, Brew S, Kitchen N, Zrinzo L (2013) Strawberries on the brain—intracranial capillary hemangioma: two case reports and systematic literature review in children and adults. World Neurosurg 80(6):900 e913–900 e921. doi:10.1016/j.wneu.2012.12.013

    Article  Google Scholar 

  9. Muzumdar D, Michaud J, Ventureyra EC (2006) Primary giant congential infantile fibrosarcoma of the scalp: case report and review of literature. Childs Nerv Syst 22(3):300–304. doi:10.1007/s00381-005-1199-0

    Article  PubMed  Google Scholar 

  10. North PE, Waner M, Mizeracki A, Mihm MC Jr (2000) GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 31(1):11–22. doi:10.1016/S0046-8177(00)80192-6

    Article  CAS  PubMed  Google Scholar 

  11. Restrepo R, Palani R, Cervantes LF, Duarte AM, Amjad I, Altman NR (2011) Hemangiomas revisited: the useful, the unusual and the new. Part 1: overview and clinical and imaging characteristics. Pediatr Radiol 41(7):895–904. doi:10.1007/s00247-011-2076-5

    Article  PubMed  Google Scholar 

  12. Spock CL, Tom LK, Canadas K, Sue GR, Sawh-Martinez R, Maier CL, Pober JS, Galan A, Schultz B, Waner M, Narayan D (2014) Infantile hemangiomas exhibit neural crest and pericyte markers. Ann Plast Surg. doi:10.1097/SAP.0000000000000080

    Google Scholar 

  13. Viswanathan V, Smith ER, Mulliken JB, Fishman SJ, Kozakewich HP, Burrows PE, Orbach DB (2009) Infantile hemangiomas involving the neuraxis: clinical and imaging findings. AJNR Am J Neuroradiol 30(5):1005–1013. doi:10.3174/ajnr.A1478

    Article  CAS  PubMed  Google Scholar 

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Tel Aviv Medical Center, Tel Aviv, Israel

    Liat Ben-Sira

  2. Department of Pediatric Neurosurgery, Dana Children’s Hospital, Tel Aviv Medical Center, 6 Weizman Street, 64239, Tel Aviv, Israel

    Shlomi Constantini & Jonathan Roth

  3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Liat Ben-Sira, Shlomi Constantini & Jonathan Roth

  4. Rappaport School of Medicine, Technion, Haifa, Israel

    Haggai Benvenisti

Authors
  1. Haggai Benvenisti
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  2. Liat Ben-Sira
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  3. Shlomi Constantini
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  4. Jonathan Roth
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Corresponding author

Correspondence to Jonathan Roth.

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The manuscript does not contain clinical studies or patient data.

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Benvenisti, H., Ben-Sira, L., Constantini, S. et al. Giant cranial and cerebellar hemangioma treated with propranolol. Childs Nerv Syst 31, 805–808 (2015). https://doi.org/10.1007/s00381-014-2603-4

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  • DOI: https://doi.org/10.1007/s00381-014-2603-4

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