Skip to main content

Advertisement

Log in

Central nervous system infection after Onyx embolisation of arterio-venous malformations in two paediatric patients

  • Case Report
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Background

Increasingly, Onyx is used for endovascular embolization of aneurysms and arterio-venous malformations. Although reports in the literature on the use of Onyx are favourable, there have been so far no reports on the central nervous system (CNS) infection rate after embolisation with Onyx and no recommendations as to the management of these infections.

Case reports

We present two cases of paediatric patients who acquired CNS infection with Pseudomonas aeruginosa after Onyx embolisation of AVMs and describe their subsequent management.

Conclusions

Presence of established infection after Onyx embolisation should be dealt with by removal of infected material, administration of appropriate antibiotic therapy and supportive treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Ayad M, Eskioglu E, Mericle A (2006) Onyx: a unique neuroembolic agent. Exp Rev Med Devices 3(6):705–715

    Article  CAS  Google Scholar 

  2. Cekirge S et al (2006) Late angiographic and clinical follow-up results of 100 consecutive aneurysms treated with Onyx reconstruction: largest single-center experience. Neuroradiology 48:113–126

    Article  PubMed  Google Scholar 

  3. Grandhi R, Zwagerman NT, Linares G, Monaco EA 3rd, Jovin T Horowitz M, Jankovitz BT (2013) Onyx embolization of infectious intracranial aneurysms. J Neurointerv Surg – epub ahead of print

  4. Jadhav AP, Pryor JC, Nogueira RG (2013) Onyx embolization for the endovascular treatment of infectious and traumatic aneurysms involving the cranial and cerebral vasculature. J Neurointerv Surg 5(6):562–565

    Article  PubMed  Google Scholar 

  5. Jahan R et al (2001) Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients. Neurosurgery 48(5):984–995

    Article  CAS  PubMed  Google Scholar 

  6. Molyneux A, Cekirge S, Saatci I, Gal G (2004) Cerebral Aneurysm Multicenter European Onyx (CAMEO) Trial: results of a prospective observational study in 20 European centers. Am J Neuroradiol 25:39–51

    PubMed  Google Scholar 

  7. Saatci I, Gevik S, Yavuz K, Cekirge S (2011) Endovascular treatment of brain arteriovenous malformations with prolonged intranidal Onyx injection technique: long-term results in 350 consecutive patients with completed endovascular treatment course. J Neurosurg 115:78–88

    Article  PubMed  Google Scholar 

  8. Stenehjem E, Armstrong W (2012) Central nervous system device infections. Infect Dis Clin N Am 26:89–110

    Article  Google Scholar 

  9. Taki W et al (1990) A new liquid material for embolization of arterio-venous malformations. Am J Neuroradiol 11:163–168

    CAS  PubMed  Google Scholar 

  10. Thiex R et al (2011) Safety and clinical efficacy of Onyx for embolization of extracranial head and neck vascular abnormalities. Am J Neuroradiol 32:1082–1086

    Article  CAS  PubMed  Google Scholar 

  11. Xu F et al (2010) Onyx embolization for the treatment of brain arteriovenous malformations. Acta Neurochir 153:869–878

    Article  PubMed  Google Scholar 

Download references

Competing interest and funding

The authors declare that they have no conflict of interest, and no funding was secured in the preparation of this manuscript.

We would like to acknowledge and thank Dr. S Brew, consultant radiologist, who was instrumental in treating these patients.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to H. Pulhorn.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pulhorn, H., Hartley, J.C., Shanmuganathan, M. et al. Central nervous system infection after Onyx embolisation of arterio-venous malformations in two paediatric patients. Childs Nerv Syst 30, 1577–1581 (2014). https://doi.org/10.1007/s00381-014-2447-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00381-014-2447-y

Keywords

Navigation