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Intracranial sinonasal undifferentiated carcinoma (SNUC) in a child

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Abstract

Introduction

Sinonasal undifferentiated carcinoma (SNUC) is a rare and relatively newly described clinicopathological entity of the nasal cavity and paranasal sinuses.

Case report

Authors report a 12-year-old male child with SNUC, who presented primarily with features of raised intracranial pressure without any feature pertaining to nasal cavity/orbit involvement. The large mass, however, was also predominantly intracranial resembling with solid intra-axial tumor, with its classical clinical profile.

Discussion

The authors highlight important diagnostic features, pathogenesis, and outcome of SNUC. The unique features of the only intracranial involvement are also discussed.

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References

  1. Frierson HF Jr, Mills SE, Fechner RE, Taxy JB, Levine PA (1986) Sinonasal undifferentiated carcinoma: An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol 10:771–779

    Article  PubMed  Google Scholar 

  2. Gorelick J, Ross D, Marentette L, Blaivas M (2000) Sinonasal undifferentiated carcinoma: case series and review of literature. Neurosurgery 47(3):750–755

    Article  PubMed  CAS  Google Scholar 

  3. Ghosh S, Weiss M, Streeter O, Sinha U, Commins D, Chen TC (2001) Drop metastasis from sinonasal undifferentiated carcinoma. Spine 26:1486–1491

    Article  PubMed  CAS  Google Scholar 

  4. Greger V, Schirmacher P, Bohl J, Bornemann A, Hurter T, Passarge E, Horsthemke B (1990) Possible involvement of the retinoblastoma gene in undifferentiated sinonasal carcinoma. Cancer 66:1954–1959

    Article  PubMed  CAS  Google Scholar 

  5. Levine PA, Frierson HF Jr, Stewart FM, Mills E, Fechnar RE, Cantrell RW (1987) Sinonasal undifferentiaded carcinoma: a distinct and highly aggressive neoplasm. Laryngoscope 97:905–908

    PubMed  CAS  Google Scholar 

  6. Pitman KT, Lassen LF (1995) Pathologic quiz case 2: sinonasal undifferentiated carcinoma (SNUC). Arch Otolaryngol Head Neck Surg 121:1201–1203

    PubMed  CAS  Google Scholar 

  7. Mills SE, Fechner RE (1989) “Undifferentiated” neoplasms of the sinonasal region: differential diagnosis based on clinical, light microscopic immunohistochemical and ultrastructural features. Semin Diagn Pathol 6:316–328

    PubMed  CAS  Google Scholar 

  8. Righi PD, Francis F, Aron BS, Weitzner S, Wilson KM, Gluckman J (1996) Sinonasal undifferentiated carcinoma: a 10-year experience. Am J Otolaryngol 17:167–171

    Article  PubMed  CAS  Google Scholar 

  9. Boysen M, Voss R, Solberg LA (1986) The nasal mucosa in softwood exposed furniture workers. Acta Otolaryngol 101:501–508

    Article  PubMed  CAS  Google Scholar 

  10. Sunderman FW Jr, Morgan LG, Andersen A et al (1989) Histopathology of sinonasal and lung cancers in nickel refinery workers. Ann Clin Lab Sci 19:44–50

    PubMed  Google Scholar 

  11. Frierson HF Jr, Ross GW, Stewart FM, Newman SA, Kelly MD (1989) Unusual sinonasal small-cell neoplasm following radiotherapy for bilateral retinoblastomas. Am J Surg Pathol 13:947–954

    Article  PubMed  Google Scholar 

  12. Gallo O, Di Lollo S, Graziani P, Gallina E, Baroni G (1995) Detection of Epstein–Barr virus genome in sinonasal undifferentiated carcinoma by use of in situ hybridization. Otolaryngol Head Neck Surg 112:659–664

    Article  PubMed  CAS  Google Scholar 

  13. Lopategui JR, Gaffey MJ, Frierson HF Jr, Chan JK, Mills SE, Chang KL, Chen YY, Weiss LM (1994) Detection of epstein Barr viral RNA in sinonasal undifferentiated carcinoma from western and Asian Patients. Am J Surg Pathol 18:391–398

    PubMed  CAS  Google Scholar 

  14. Kin S, Wanibuchi M, Minamida Y, Yamaki T, Tanabe S, Houkin K (2003) A case of sinonasal carcinoma with intracranial invasion treated by a multidisciplinary team. No Shinkei Geka 31(6):677–682 (Article in Japanese)

    PubMed  Google Scholar 

  15. Deutsch BD, Levine PA, Stawart FM et al (1993) Sinonasal undifferentiated carninoma: a ray of hope. Otolaryngol Head Neck Surg 108:697–700

    PubMed  CAS  Google Scholar 

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Acknowledgement

The authors are extremely grateful to Mr. A. P. Dhar Dwivedi, from the Department of Neurosurgery, SGPGIMS, Lucknow, India, for providing secretarial assistance during the completion of this manuscript.

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Correspondence to Raj Kumar.

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Kumar, R., Chandra, A. & Rastogi, A. Intracranial sinonasal undifferentiated carcinoma (SNUC) in a child. Childs Nerv Syst 22, 1208–1211 (2006). https://doi.org/10.1007/s00381-006-0066-y

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  • DOI: https://doi.org/10.1007/s00381-006-0066-y

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