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Zinc supplementation in patients with acute myocardial infarction

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Abstract

This single-centre prospective feasibility study (UMIN000030232) evaluated whether zinc supplementation was safe and effective for improving outcomes among patients with acute myocardial infarction (AMI). Within 24 h after successful primary percutaneous coronary intervention, consenting patients with AMI were randomly assigned 1:1 to receive conventional treatment (conventional treatment group) or conventional treatment plus zinc acetate supplementation (zinc supplementation group). The two groups were compared in terms of major adverse cardiovascular events (MACE), and scar size, which was evaluated using cardiac magnetic resonance imaging (CMR) at 4 weeks after discharge. A total of 56 patients underwent randomization (with 26 assigned to the zinc supplementation group and 27 to the conventional treatment group). The two groups had generally similar laboratory findings and clinical characteristics. The two groups also had similar lengths of hospital stay and rates of MACE. Forty of the 53 patients underwent CMR and it revealed that % core zone was numerically lower in the zinc supplementation group than in the conventional treatment group (9.3 ± 6.9% vs. 14.2 ± 9.1%, P = 0.07). This small single-centre study failed to detect a significant reduction in mid-term MACE after AMI among patients who received zinc supplementation.

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The data underlying this article cannot be shared publicly due to the privacy of individuals that participated in the study. The data will be shared on reasonable request to the corresponding author.

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Funding

This study was not supported by any funding.

Author information

Authors and Affiliations

  1. Showa University Northern Yokohama Hospital Division of Cardiology, 35-1, Chigasaki-Chuo, Tsuzuki, Yokohama, 224-8503, Japan

    Toshitaka Okabe, Tadayuki Yakushiji, Shuro Narui, Tatsuki Fujioka, Shigehiro Ishigaki, Soichiro Usumoto, Yu Asukai, Taro Kimura, Suguru Shimazu, Jumpei Saito, Yuji Oyama, Takehiko Kido, Wataru Igawa, Morio Ono, Seitaro Ebara, Myong Hwa Yamamoto, Naoei Isomura & Masahiko Ochiai

Authors
  1. Toshitaka Okabe
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  2. Tadayuki Yakushiji
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  3. Shuro Narui
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  4. Tatsuki Fujioka
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  5. Shigehiro Ishigaki
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  6. Soichiro Usumoto
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  7. Yu Asukai
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  17. Naoei Isomura
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  18. Masahiko Ochiai
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Contributions

SN, TF, SI, SU, YA, TK, SS, JS, YO, TK, WI, MO, SE, and NI treated the patients and collected the data and helped draft the manuscript. MY helped perform the statistical analysis. TY and MO participated in the study design and coordination and helped draft the manuscript. TO participated in the study design and wrote the manuscript.

Corresponding author

Correspondence to Toshitaka Okabe.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Institutional Review Board.

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All patients provided written informed consent.

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Okabe, T., Yakushiji, T., Narui, S. et al. Zinc supplementation in patients with acute myocardial infarction. Heart Vessels 38, 889–897 (2023). https://doi.org/10.1007/s00380-023-02239-8

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  • DOI: https://doi.org/10.1007/s00380-023-02239-8

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