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Relation of glucose variability to vulnerable plaque formation in patients with coronary artery disease

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Abstract

Background

Although glucose variability (GV) is reportedly associated with coronary plaque vulnerability, namely lipid-rich plaque, details are not fully understood. The aim of this study was to evaluate relations of GV after discharge to vulnerable plaque formation assessed by near-infrared spectroscopy intravascular ultrasound (NIRS-IVUS) in patients with and without diabetes.

Methods

A total of 40 patients undergoing percutaneous coronary intervention under NIRS-IVUS guidance were included, among whom 13 (33%) had diabetes and 20 (50%) presented with acute myocardial infarction (MI). GV was evaluated by a flush glucose monitoring system, primarily with mean amplitude of glycemic excursion (MAGE). Lipid-rich plaque was assessed by maximum lipid core burden index in 4 mm (maxLCBI4mm) in the target lesion using NIRS-IVUS.

Results

Mean MAGE and maxLCBI4mm were 69.7 ± 25.6 mg/dl and 508.0 ± 294.9. Intra-day GV was not significantly associated with maxLCBI4mm in the entire study population, while MAGE was correlated with maxLCBI4mm in non-diabetic patients (r = 0.46, p = 0.02). In patients with and without acute MI presentation, no significant relations were found between MAGE and maxLCBI4mm.

Conclusion

GV was associated with lipid core plaque formation, especially in non-diabetic patients.

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Acknowledgements

We thank all of the hospital staff who assisted in data collection.

Funding

This study was funded by the Nipro Corporation.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan

    Kazuya Tateishi, Yuichi Saito, Hideki Kitahara & Yoshio Kobayashi

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  1. Kazuya Tateishi
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Correspondence to Kazuya Tateishi.

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Yoshio Kobayashi has received research grants from the Nipro Corporation.

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Tateishi, K., Saito, Y., Kitahara, H. et al. Relation of glucose variability to vulnerable plaque formation in patients with coronary artery disease. Heart Vessels 37, 1516–1525 (2022). https://doi.org/10.1007/s00380-022-02063-6

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  • DOI: https://doi.org/10.1007/s00380-022-02063-6

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