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Heart and Vessels

, Volume 33, Issue 7, pp 752–759 | Cite as

High-intensity aerobic interval training can lead to improvement in skeletal muscle power among in-hospital patients with advanced heart failure

  • Masanobu Taya
  • Eisuke AmiyaEmail author
  • Masaru Hatano
  • Hisataka Maki
  • Daisuke Nitta
  • Akihito Saito
  • Masaki Tsuji
  • Yumiko Hosoya
  • Shun Minatsuki
  • Atsuko Nakayama
  • Takayuki Fujiwara
  • Yuto Konishi
  • Kazuhiko Yokota
  • Masafumi Watanabe
  • Hiroyuki Morita
  • Nobuhiko Haga
  • Issei Komuro
Original Article

Abstract

This study investigated the effectiveness and safety of interval training during in-hospital treatment of patients with advanced heart failure. Twenty-four consecutive patients with advanced symptomatic heart failure who were referred for cardiac transplant evaluation were recruited. After performing aerobic exercise for approximate intensity, high-intensity interval training (HIIT) was performed. The protocol consisted of 3 or 4 sessions of 1-min high-intensity exercise aimed at 80% of peak VO2 or 80% heart rate reserve, followed by 4-min recovery periods of low intensity. In addition to the necessary laboratory data, hand grip strength and knee extensor strength were evaluated at the start of exercise training and both at the start and the end of HIIT. Knee extensor strength was standardized by body weight. The BNP level at the start of exercise training was 432 (812) pg/mL and it significantly decreased to 254 (400) pg/mL (p < 0.001) at the end of HIIT. Hand grip strength did not change during course. By contrast, knee extensor strength significantly increased during HIIT [4.42 ± 1.43 → 5.28 ± 1.45 N/kg, p < 0.001], whereas the improvement of knee extensor strength was not significant from the start of exercise training to the start of HIIT. In addition, the change in knee extensor strength during HIIT was significantly associated with the hemoglobin A1c level at the start of exercise (R = − 0.55; p = 0.015). HIIT has a positive impact on skeletal muscle strength among in-hospital patients with advanced heart failure.

Keywords

Cardiac rehabilitation Heart failure Muscle strength High-intensity interval training 

Notes

Acknowledgements

This work was supported by The Ministry of Education, Culture, Sports, Science and Technology of Japan through Grant-in-aid 26,461,103 (to Amiya E).

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

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Copyright information

© Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Masanobu Taya
    • 1
    • 2
  • Eisuke Amiya
    • 1
    Email author
  • Masaru Hatano
    • 1
    • 3
  • Hisataka Maki
    • 1
  • Daisuke Nitta
    • 1
  • Akihito Saito
    • 1
  • Masaki Tsuji
    • 1
  • Yumiko Hosoya
    • 1
  • Shun Minatsuki
    • 1
  • Atsuko Nakayama
    • 1
  • Takayuki Fujiwara
    • 1
  • Yuto Konishi
    • 1
    • 2
  • Kazuhiko Yokota
    • 2
  • Masafumi Watanabe
    • 1
  • Hiroyuki Morita
    • 1
  • Nobuhiko Haga
    • 2
  • Issei Komuro
    • 1
  1. 1.Department of Cardiovascular Medicine, Graduate School of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of Rehabilitation, Graduate School of MedicineThe University of TokyoTokyoJapan
  3. 3.Department of Therapeutic Strategy for Heart Failure, Graduate School of MedicineThe University of TokyoTokyoJapan

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