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Prognostic importance of comorbidities in heart failure with preserved left ventricular ejection fraction

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Abstract

The relative impact of comorbidities and parameters of left ventricular diastolic function on clinical outcome has not been thoroughly investigated in patients who are hospitalized for heart failure decompensation and found to have preserved ejection fraction. We identified 98 HFpEF patients among 1452 patients admitted with acute heart failure. Clinical characteristics, hemoglobin levels, estimated glomerular filtration rate (eGFR), B-type natriuretic peptide (BNP) and Doppler-echocardiographic parameters were analyzed. The primary end point of the study combined death and rehospitalization for decompensated heart failure after the index hospitalization. Mean age was 76 ± 9 years. LV ejection fraction, E/E a ratio, and estimated systolic pulmonary artery pressure were 61 (55–67)%, 12.9 (9.4–15.1), 40 (32–46) mmHg, respectively. BNP values, hemoglobin and eGFR were 287 (164–562) pg/mL, 11.3 (10.4–12.4) g/dL and 45 (37–74) mL/min/m2, respectively. During a mean follow-up of 17 ± 11 months, 56% reached the primary endpoint of the study: 31 died and 24 were re-hospitalizated for heart failure. Diabetes [HR = 1.76 (1.03–3.00), P = 0.039], lower systolic blood pressure [HR = 0.99 (0.97–0.99), P = 0.016], hemoglobin [HR = 0.62 (0.49–0.76), P < 0.0001], and eGFR [HR = 0.98 (0.97–0.99), P = 0.004] were associated with a poor outcome. Neither BNP nor echocardiographic parameters were correlated with outcome. Comorbidities primarily correlate with outcome in patients with HFpEF.

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Authors and Affiliations

  1. Division of Cardiology, Centre Hospitalier Régional et Universitaire de Lille, 59019, Lille, France

    Sylvestre Maréchaux, Marie M. Six-Carpentier, Nadia Bouabdallaoui, David Montaigne, Jean Jacques Bauchart, Frédéric Mouquet, Jean Luc Auffray, Thierry Le Tourneau, Philippe Asseman & Pierre Vladimir Ennezat

  2. Faculté de médecine, Université de Lille 2, IFR 114, EA 2693, 59045, Lille, France

    Sylvestre Maréchaux, Marie M. Six-Carpentier, Nadia Bouabdallaoui, David Montaigne, Jean Jacques Bauchart, Frédéric Mouquet, Jean Luc Auffray, Thierry Le Tourneau, Philippe Asseman & Pierre Vladimir Ennezat

  3. Division of Cardiology, Tulane University School of Medicine, New Orleans, LA, USA

    Thierry H. LeJemtel

  4. Cardiology Intensive Care Unit, Cardiology Hospital, Bd Pr J Leclercq, 59037, Lille Cedex, France

    Pierre Vladimir Ennezat

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  1. Sylvestre Maréchaux
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Correspondence to Pierre Vladimir Ennezat.

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S. Maréchaux and M. M. Six-Carpentier contributed equally to the preparation of the manuscript.

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Maréchaux, S., Six-Carpentier, M.M., Bouabdallaoui, N. et al. Prognostic importance of comorbidities in heart failure with preserved left ventricular ejection fraction. Heart Vessels 26, 313–320 (2011). https://doi.org/10.1007/s00380-010-0057-5

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