Abstract
Catecholamines increase arterial pressure by increasing cardiac output (Q) and stroke volume (V s), while angiotensin II (ang II) also increases vascular resistance (R sys) in the Antarctic fish Pagothenia borchgrevinki. Adrenaline, phenylephrine and ang II (Asn1, Val5) were injected into P. borchgrevinki. Cardiovascular variables, including central venous pressure (P cv) and mean circulatory filling pressure (P mcf; an index of venous capacitance), were recorded to investigate if venous vasoconstriction can explain the increased V s and Q and the arterial pressor response in this species. Routine P cv and P mcf were 0.11 ± 0.01 and 0.18 ± 0.02 kPa, respectively. All of the drugs caused moderate increases in P cv and P mcf and the responses were attenuated after α-adrenergic blockade with prazosin. Although dorsal aortic pressure (P da) also increased in response to all agonists, the mechanisms differed. Adrenaline caused sustained increases in V s and Q, while R sys only rose transiently. Ang II had a slower effect than adrenaline and increased both R sys and Q, while phenylephrine only increased R sys. This study demonstrates that P cv is positive and controlled by an α-adrenergic mechanism in P. borchgrevinki. However, given the relatively small venous response to adrenaline it seems more likely that the increases in V s and Q from this agonist are due to direct effects on the heart.
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Acknowledgments
The authors would like to thank Antarctica New Zealand and base staff of Scott Base for logistics support and the ability to visit and work in Antarctica. M. A. was financially supported by research grants from the Swedish research council and E. S. was supported by a travel grant from the Swedish research council.
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Communicated by G. Heldmaier.
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Sandblom, E., Axelsson, M. & Davison, W. Circulatory function at sub-zero temperature: venous responses to catecholamines and angiotensin II in the Antarctic fish Pagothenia borchgrevinki . J Comp Physiol B 179, 165–173 (2009). https://doi.org/10.1007/s00360-008-0299-z
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DOI: https://doi.org/10.1007/s00360-008-0299-z