Auditory cortical responses to amplitude modulations with spectra above frequency receptive fields: evidence for wide spectral integration

Abstract

Auditory neurons typically respond to a restricted range of frequencies and amplitudes of pure tone stimuli. These findings have led to the concept of the classical frequency receptive field. Over the last few years evidence has accumulated that stimuli outside the frequency and amplitude boundaries of a neuron's receptive field can influence responses to stimuli inside the classical receptive field. We could recently show that sinusoidally amplitude-modulated pure tones could excite cortical neurons although all of their spectral components were above the spectral range of pure tones effective to excite the neuron. This result demonstrated that neurons in the auditory cortex integrate over spectral ranges that are much wider than is evident from responses to pure tones. Here, using sinusoidally amplitude-modulated pure tone stimuli we determine electrophysiologically the high-frequency boundaries of the spectral integration capabilities of auditory cortical neurons in anaesthetized Mongolian gerbils under normal conditions and under the influence of the microiontophoretically applied GABA_A-receptor antagonist bicuculline. Our results demonstrate that some auditory cortical neurons integrate over the gerbil's entire audible spectrum. Therefore, the classical excitatory frequency receptive field of an auditory cortical neuron, as determined with pure tone stimuli, cannot provide a satisfactory description of its spectral integrative properties.