Direction-dependent corticofugal modulation of frequency-tuning curves of inferior collicular neurons in the big brown bat, Eptesicus fuscus

Abstract.

This study examined if corticofugal modulation of subcortical frequency-tuning curves varied with sound direction. Both excitatory and inhibitory frequency tuning curves of inferior collicular neurons of the big brown bat, Eptesicus fuscus were plotted before and during electrical stimulation in the auditory cortex at two sound directions (contra-40° and ipsi-40°). Most collicular neurons had broader excitatory frequency-tuning curves at contra-40° but had broader inhibitory frequency-tuning curves at ipsi-40°. Cortical electrical stimulation changed the excitatory minimum thresholds of most collicular neurons at a greater degree at ipsi-40° than at contra-40°. However, cortical electrical stimulation produced a greater increase in the sharpness of excitatory frequency-tuning curves of most corticofugally inhibited collicular neurons at contra-40° but produced a greater decrease in the sharpness of excitatory frequency-tuning curves of most corticofugally facilitated collicular neurons at ipsi-40°. Cortical electrical stimulation also produced a greater change in the sharpness of inhibitory frequency-tuning curves of most corticofugally inhibited collicular neurons at contra-40° than at ipsi-40°. Possible mechanisms for this direction-dependent corticofugal modulation of frequency-tuning curves of collicular neurons are discussed.