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Circumcision plus antibiotic, anti-inflammatory, and α-blocker therapy for the treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, multicenter trial

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Abstract

Purpose

The purpose of the study was to evaluate the efficacy of circumcision combined with antibiotic, anti-inflammatory, and α-blocker therapy for the treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods

Subjects assigned to the circumcision group were given antibiotic, anti-inflammatory, and α-blocker medications and scheduled for surgery the same period in each site by study clinicians. Subjects assigned to the control group were asked to only take the same medications and remain uncircumcised until the end of the 3-month study period. The primary outcome was a reduction of at least four points on the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI).

Results

A total of 774 eligible participants underwent randomization, and the ratio of men with a decrease of at least four points on the total NIH-CPSI score from baseline to 12 weeks was 84.6 % in the circumcision group and 68.5 % in the control group (P < 0.001). Of the 713 men who completed the trial, the median total NIH-CPSI score decreased significantly from 21.0 ± 7.0 to 12.0 ± 8.0 (P < 0.001) in the circumcision group, and in the control group, the change was from 21.0 ± 8.0 to 15.0 ± 7.0 (P < 0.001). Comparison of the changes in the total and three subdomain NIH-CPSI scores over time revealed significant differences between the circumcision and control groups (P < 0.001).

Conclusions

Our findings show that circumcision plus antibiotic, anti-inflammatory, and α-blocker therapy for CP/CPPS patients resulted in improved NIH-CPSI scores compared with medication therapy only.

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Acknowledgments

This study was supported by the Shanghai Public Health Bureau with additional support from Shanghai First People’s Hospital.

Conflict of interest

All authors declare no competing interests.

Ethical standard

Study approval was granted by the Ethics Review Committee of Shanghai First People’s Hospital, and written informed consent was obtained from all patients.

Author information

Authors and Affiliations

  1. Department of Urology, Shanghai First People’s Hospital, Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China

    Yuyang Zhao, Wei Zhao, Dongliang Xu & Shujie Xia

  2. Department of Urology, Shanghai 411 Hospital, Shanghai, 200000, China

    Genqiang Lang

  3. Department of Urology, Shanghai First People’s Hospital (Baoshan Branch), Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200940, China

    Yaowu Chen

  4. Department of Urology, Shanghai TCM-Integrated Hospital, Shanghai, 200028, China

    Jianxin Liu

  5. Department of Urology, Shanghai Gongli Hospital, Shanghai, 200135, China

    Guozeng Wang

  6. Department of Urology, Shanghai Jiangwan Hospital, Shanghai, 200434, China

    Xiaobing Ma

  7. Department of Urology, Shanghai Pudong Hospital, Shanghai, 201399, China

    Min Gong

Authors
  1. Yuyang Zhao
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  2. Wei Zhao
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  3. Genqiang Lang
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  4. Yaowu Chen
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  5. Jianxin Liu
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  6. Guozeng Wang
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  7. Xiaobing Ma
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  8. Min Gong
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  9. Dongliang Xu
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  10. Shujie Xia
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Corresponding authors

Correspondence to Dongliang Xu or Shujie Xia.

Additional information

Yuyang Zhao and Wei Zhao have contributed equally to this work.

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Zhao, Y., Zhao, W., Lang, G. et al. Circumcision plus antibiotic, anti-inflammatory, and α-blocker therapy for the treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, multicenter trial. World J Urol 33, 617–622 (2015). https://doi.org/10.1007/s00345-014-1350-1

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  • DOI: https://doi.org/10.1007/s00345-014-1350-1

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