Abstract
Purpose
The role of HistoScanning™ (HS) in prostate biopsy is still indeterminate. Existing literature is sparse and controversial. To provide more evidence according to that important clinical topic, we analyzed institutional data from the Martini-Clinic, Prostate Cancer Center, Hamburg.
Methods
Patients who received prostate biopsy and who also received HS were included in the study cohort. A single examiner, blinded to pathological results, re-analyzed all HS data in accordance with sextants of the prostate. Each sextant was considered as an individual case. Corresponding results from biopsy and HS were analyzed. The area under the receiver-operating characteristic curve (AUC) for the prediction of a positive biopsy by HS was calculated. Furthermore, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were assessed according to different HS signal volume cutoffs (>0, >0.2 and >0.5 ml).
Results
Overall, 198 men were identified and 1,188 sextants were analyzed. The AUC to predict positive biopsy results by HS was 0.58. Sensitivity, specificity, PPV and NPV for HS to predict positive biopsy results per sextant, depending on different HS signal volume cutoffs (>0, >0.2 and >0.5 ml) were 84.1, 27.7, 29.5 and 82.9 %, 60.9, 50.6, 28.8 and 79.7 %, and 40.1, 73.3, 33.1 and 78.8 %, respectively.
Conclusions
Positive HS signals do not accurately predict positive prostate biopsy results according to sextant analysis. We cannot recommend a variation of well-established random biopsy patterns or reduction of biopsy cores in accordance with HS signals at the moment.
Similar content being viewed by others
References
Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, Mottet N, Schmid HP, van der Kwast T, Wiegel T, Zattoni F (2011) EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease. Eur Urol 59(1):61–71. doi:10.1016/j.eururo.2010.10.039
Kawachi MH, Bahnson RR, Barry M, Busby JE, Carroll PR, Carter HB, Catalona WJ, Cookson MS, Epstein JI, Etzioni RB, Giri VN, Hemstreet GP III, Howe RJ, Lange PH, Lilja H, Loughlin KR, Mohler J, Moul J, Nadler RB, Patterson SG, Presti JC, Stroup AM, Wake R, Wei JT (2010) NCCN clinical practice guidelines in oncology: prostate cancer early detection. J Natl Compr Cancer Netw 8(2):240–262
Schroder FH, van den Bergh RC, Wolters T, van Leeuwen PJ, Bangma CH, van der Kwast TH, Roobol MJ (2010) Eleven-year outcome of patients with prostate cancers diagnosed during screening after initial negative sextant biopsies. Eur Urol 57(2):256–266. doi:10.1016/j.eururo.2009.10.031
Chun FK, Briganti A, Graefen M, Montorsi F, Porter C, Scattoni V, Gallina A, Walz J, Haese A, Steuber T, Erbersdobler A, Schlomm T, Ahyai SA, Currlin E, Valiquette L, Heinzer H, Rigatti P, Huland H, Karakiewicz PI (2007) Development and external validation of an extended 10-core biopsy nomogram. Eur Urol 52(2):436–444. doi:10.1016/j.eururo.2006.08.039
Benecchi L, Pieri AM, Melissari M, Potenzoni M, Pastizzaro CD (2008) A novel nomogram to predict the probability of prostate cancer on repeat biopsy. J Urol 180(1):146–149. doi:10.1016/j.juro.2008.03.043
Rochester MA, Pashayan N, Matthews F, Doble A, McLoughlin J (2009) Development and validation of risk score for predicting positive repeat prostate biopsy in patients with a previous negative biopsy in a UK population. BMC Urol 9:7. doi:10.1186/1471-2490-9-7
Bul M, Zhu X, Valdagni R, Pickles T, Kakehi Y, Rannikko A, Bjartell A, van der Schoot DK, Cornel EB, Conti GN, Boeve ER, Staerman F, Vis-Maters JJ, Vergunst H, Jaspars JJ, Strolin P, van Muilekom E, Schroder FH, Bangma CH, Roobol MJ (2013) Active surveillance for low-risk prostate cancer worldwide: the PRIAS study. Eur Urol 63(4):597–603. doi:10.1016/j.eururo.2012.11.005
Neill MG, Toi A, Lockwood GA, Evans A, Tammsalu L, Fleshner NE (2008) Systematic lateral prostate biopsy—are the benefits worth the costs? J Urol 179(4):1321–1326. doi:10.1016/j.juro.2007.11.065
Simmons LA, Autier P, Zat’ura F, Braeckman J, Peltier A, Romic I, Stenzl A, Treurnicht K, Walker T, Nir D, Moore CM, Emberton M (2012) Detection, localisation and characterisation of prostate cancer by prostate HistoScanning(). BJU Int 110(1):28–35. doi:10.1111/j.1464-410X.2011.10734.x
Braeckman J, Autier P, Garbar C, Marichal MP, Soviany C, Nir R, Nir D, Michielsen D, Bleiberg H, Egevad L, Emberton M (2008) Computer-aided ultrasonography (HistoScanning): a novel technology for locating and characterizing prostate cancer. BJU Int 101(3):293–298. doi:10.1111/j.1464-410X.2007.07232.x
Braeckman J, Autier P, Soviany C, Nir R, Nir D, Michielsen D, Treurnicht K, Jarmulowicz M, Bleiberg H, Govindaraju S, Emberton M (2008) The accuracy of transrectal ultrasonography supplemented with computer-aided ultrasonography for detecting small prostate cancers. BJU Int 102(11):1560–1565. doi:10.1111/j.1464-410X.2008.07878.x
Salomon G, Spethmann J, Beckmann A, Autier P, Moore C, Durner L, Sandmann M, Haese A, Schlomm T, Michl U, Heinzer H, Graefen M, Steuber T (2013) Accuracy of HistoScanning for the prediction of a negative surgical margin in patients undergoing radical prostatectomy. BJU Int 111(1):60–66. doi:10.1111/j.1464-410X.2012.11396.x
Hamann MF, Hamann C, Schenk E, Al-Najar A, Naumann CM, Junemann KP (2013) Computer-aided (HistoScanning) biopsies versus conventional transrectal ultrasound-guided prostate biopsies: do targeted biopsy schemes improve the cancer detection rate? Urology 81(2):370–375. doi:10.1016/j.urology.2012.08.072
Nunez-Mora C, Garcia-Mediero JM, Patino P, Orellana C, Garrido A, Rojo A, Rendon D (2013) Utility of Histoscanning prior to prostate biopsy for the diagnosis of prostate adenocarcinoma. Actas Urol Esp. doi:10.1016/j.acuro.2013.01.003
Macek P, Barret E, Sanchez-Salas R, Galiano M, Rozet F, Ahallal Y, Gaya JM, Durant M, Mascle L, Giedelman C, Lunelli L, Validire P, Nesvadba M, Cathelineau X (2013) Prostate Histoscanning in clinically localized biopsy proven prostate cancer: an accuracy study. J Endourol. doi:10.1089/end.2013.0419
Schiffmann J, Fischer J, Tennstedt P, Beyer B, Bohm K, Michl U, Graefen M, Salomon G (2013) Comparison of prostate cancer volume measured by HistoScanning and final histopathological results. World J Urol. doi:10.1007/s00345-013-1211-3
Javed SCE, Beveridge S, Bott S, Eden C, Langley S (2013) Does prostate HistoscanningTM accurately identify prostate cancer, measure tumour volume and assess pathological stage prior to radical prostatectomy? J Clin Urol. doi:10.1177/2051415813489682
Javed S, Chadwick E, Edwards AA, Beveridge S, Laing R, Bott S, Eden C, Langley S (2013) Does HistoScanning play a role in detecting prostate cancer in routine clinical practice? Results from three independent studies. BJU Int. doi:10.1111/bju.12568
D’Amico AV, Whittington R, Malkowicz SB, Schultz D, Blank K, Broderick GA, Tomaszewski JE, Renshaw AA, Kaplan I, Beard CJ, Wein A (1998) Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280(11):969–974
Salomon G, Schiffmann J (2014) Real-time elastography for the detection of prostate cancer. Curr Urol Rep 15(3):392. doi:10.1007/s11934-013-0392-z
Bjurlin MA, Meng X, Le Nobin J, Wysock JS, Lepor H, Rosenkrantz AB, Taneja SS (2014) Optimization of prostate biopsy: the role of MRI targeted biopsy in detection, localization, and risk assessment. J Urol. doi:10.1016/j.juro.2014.03.117
Moore CM, Robertson NL, Arsanious N, Middleton T, Villers A, Klotz L, Taneja SS, Emberton M (2013) Image-guided prostate biopsy using magnetic resonance imaging-derived targets: a systematic review. Eur Urol 63(1):125–140. doi:10.1016/j.eururo.2012.06.004
Conflict of interest
The authors declare that they have no conflicts of interest.
Ethical standard
The study was approved by the local ethics committee of the Medical Board Hamburg (PV3848).
Author information
Authors and Affiliations
Corresponding author
Additional information
J. Schiffmann and P. Tennstedt have contributed equally to this manuscript.
Rights and permissions
About this article
Cite this article
Schiffmann, J., Tennstedt, P., Fischer, J. et al. Does HistoScanning™ predict positive results in prostate biopsy? A retrospective analysis of 1,188 sextants of the prostate. World J Urol 32, 925–930 (2014). https://doi.org/10.1007/s00345-014-1330-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00345-014-1330-5