Skip to main content
SpringerLink
Log in

Chemical constituents of marine algal-derived endophytic fungus Exophiala oligosperma EN-21

  • Chemistry
  • Published:
Chinese Journal of Oceanology and Limnology Aims and scope Submit manuscript

Abstract

Seven compounds (1–7) were identified from the cultivation of the endophytic fungus Exophiala oligosperma (EN-21) that was isolated from the inner tissue of the marine red alga Laurencia similis. Their structures were identified with spectroscopic and chemical methods as 2-phenoxynaphthalene (1), (2S, 3R, 4E, 8E)-1-O-β-D-glucopyranosyl-3-hydroxy-2-[(R)-2′-hydroxyoctadecanoyl] amino-9-methyl-4, 8-octadeca-diene (2), (22E,24R)-ergosta-7,22-dien-3β,5α,6β-triol (3), (22E, 24R)-3β, 5α, 9α-trihydroxy-ergosta-7, 22-dien-6-one (4), (22E, 24R)-5α, 6α-epoxy-ergosta-8, 22-dien-3β, 7α-diol (5), (22E, 24R)-ergosta-4, 6, 8(14), 22-tetraen-3-one (6), and euphorbol (7). This paper reports for the first time the chemical constituents of fungus Exophiala oligosperma and the discovery of compound 1 as a natural product from the fungus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Akihisa T, Wijeratne E M K, Tokuda H, Enjo F, Toriumi M, Kimura Y, Koike K, Nikaido T, Tezuka Y, Nishino H. 2002. Eupha-7, 9(11), 24-trien-3β-ol (“Antiquol C”) and other triterpenes from Euphorbia antiquorum Latex and their inhibitory effects on epstein-barr virus activation. J. Nat. Prod. 65(2): 158–162.

    Article  Google Scholar 

  • Batrakov S G, Konova I V, Sheichenko V I, Esipov S E, Galanina L A, Istratova L N. 2002. Unusual fatty acid composition of cerebrosides from the filamentous soil fungus Mortierella alpine. Chem. Phys. Lipids. 117(1): 45–51.

    Article  Google Scholar 

  • Cui C M, Li X M, Li C S, Sun H F, Gao S S, Wang B G. 2009. Benzodiazepine alkaloids from marine-derived endophytic fungus Aspergillus ochraceus. Helv. Chim. Acta. 92(7):1 366–1 370.

    Article  Google Scholar 

  • dos Santos R M G, Rodrigues-Filho E. 2003. Structures of meroterpenes produced by Penicillium sp, an endophytic fungus found associated with Melia azedarach. J. Braz. Chem. Soc. 14(5): 722–727.

    Article  Google Scholar 

  • Li D L, Li X M, Li T G, Dang H Y, Proksch P, Wang B G. 2008. Benzaldehyde derivatives from Eurotium rubrum, an endophytic fungus derived from the mangrove plant Hibiscus tiliaceus. Chem. Pharm. Bull. 56(9): 1 282–1 285.

    Article  Google Scholar 

  • Li D M. 2000. Research progress on the classification and identification of Exophiala spp. Foreign Med. Sci. Microbis Section, 23(5): 24–27.

    Google Scholar 

  • Piccialli V, Sica D. 1987. Four new trihydroxylated sterols from the sponge Spongionella gracilis. J. Nat. Prod., 50(5): 915–920.

    Article  Google Scholar 

  • Thornton T A, Ross G A, Patil D, Mukaida K, Warwick J O, Woolsey N F, Bartak D E. 1989. Carbon-oxygen bond-cleavage reactions by electron transfer. 4. Electrochemical and alkali-metal reductions of phenoxynaphthalenes. J. Am. Chem. Soc. 111(7): 2 434–2 440.

    Article  Google Scholar 

  • Valisolalao J, Luu B, Ourisson G. 1983. Steroides cytotoxiques de Polyporus versicolor. Tetrahedron, 39(17): 2 779–2 785.

    Article  Google Scholar 

  • Wang S, Li X M, Teuscher F, Li D L, Diesel A, Ebel R, Proksch P, Wang B G. 2006. Chaetopyranin, a benzaldehyde derivative, and other related metabolites from Chaetomium globosum, an endophytic fungus derived from the marine red alga Polysiphonia urceolata. J. Nat. Prod. 69(12): 1 622–1 625.

    Google Scholar 

  • Yu D Q, Yang J S. 1999, Handbook of Analytical Chemistry; 7th Fascicle: NMR Spectroscopy. 2nd Edition. Beijing, Chemical Industry Press: 551; 554.

    Google Scholar 

  • Yue J M, Chen S N, Lin Z W, Sun H D. 2001. Sterols from the fungus Lactarium volemus. Phytochemistry 56(8): 801–806.

    Article  Google Scholar 

  • Zhang Y, Wang S, Li X M, Cui C M, Feng C, Wang B G. 2007. New sphingolipids with a previously unreported 9-methyl-C-20-sphingosine moiety from a marine algous endophytic fungus Aspergillus niger EN-13. Lipids, 42(8): 759–764.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China

    Fang Li  (李昉), Ke Li  (李可), Xiaoming Li  (李晓明) & Bingui Wang  (王斌贵)

  2. Graduate University of Chinese Academy of Sciences, Beijing, 100039, China

    Fang Li  (李昉) & Ke Li  (李可)

Authors
  1. Fang Li  (李昉)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ke Li  (李可)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiaoming Li  (李晓明)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bingui Wang  (王斌贵)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bingui Wang  (王斌贵).

Additional information

Supported by the Programs from the Ministry of Science and Technology of China (Nos. 2007AA09Z446, 2010CB833802), and the Knowledge Innovation Program of Chinese Academy of Sciences (KZCX2-YW-211-04)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, F., Li, K., Li, X. et al. Chemical constituents of marine algal-derived endophytic fungus Exophiala oligosperma EN-21. Chin. J. Ocean. Limnol. 29, 63–67 (2011). https://doi.org/10.1007/s00343-011-9949-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00343-011-9949-1

Keyword

Search

Navigation