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Laser-assisted method for preparation of nanocomposites based on magnetite and noble metals for biomedical applications

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Abstract

Pulsed laser ablation in liquids (PLAL) has been developed as a robust method for producing multi-element nanoparticles such as metal alloys. This has sparked considerable interest in furthering our knowledge of nanoparticle formation during PLAL, with the aim of improving control over product structure and broadening the variety of compositions achievable with this approach. In this paper, we present the fabrication of magneto-plasmonic nanoparticles based on Fe3O4/Au nanocomposite utilizing an infrared nanosecond laser for laser ablation in a liquid medium. This innovative and adaptable approach enables us to create multi-element nanosystems under non-equilibrium conditions. We thoroughly characterized the Fe3O4/Au nanocomposites using a variety of techniques, including electron microscopy, elemental analysis, X-ray diffraction, and ultraviolet–visible absorption spectroscopy. The XRD results revealed a crystalline structure composed of Au NPs and Fe3O4 NPs with no impurities present. Furthermore, increasing the laser energy also resulted in a red shift in the maximum exciton absorption (λmax), a result of the quantum confinement effect impacting the generation of electron–hole (e–h) carriers. Furthermore, our TEM images revealed a color gradient in the spherical shape, which became more pronounced with higher laser ablation power. Subsequently, we assessed the antibacterial activity of the synthesized Fe3O4/Au nanocomposite against five distinct species of bacteria using agar plate diffusion methods. This was followed by minimum inhibition concentration determination and measuring reactive oxygen species (ROS) within the treated bacterial pathogens. The findings of our research position identify laser-synthesized Fe3O4/Au nanocomposite structures as promising candidates for a variety of biomedical applications.

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Acknowledgment

This work was supported by National Research Center (NRC) of Egypt (Project No. 13020306).

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Authors and Affiliations

  1. Spectroscopy Department, Physics Research Institute, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, P.O. 12622, Giza, Egypt

    Mohammed A. Zakaria, Ayman M. Mostafa & Emad A.Al-Ashkar

  2. Microbial Chemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt

    Mohamed Abdelraof

  3. Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt

    Reem H. El-Gebaly & Ahmed S. Monem

  4. Department of Physics, College of Science, Qassim University, 51452, Buraidah, Saudi Arabia

    Ayman M. Mostafa

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  1. Mohammed A. Zakaria
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  4. Ayman M. Mostafa
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Correspondence to Ayman M. Mostafa.

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Zakaria, M.A., Abdelraof, M., El-Gebaly, R.H. et al. Laser-assisted method for preparation of nanocomposites based on magnetite and noble metals for biomedical applications. Appl. Phys. A 130, 132 (2024). https://doi.org/10.1007/s00339-024-07283-3

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