Abstract
Luminescent zirconia quantum dots (ZQDs) were prepared by wet leaf extract of Spinacia oleracea plant with varying ultrasonication treatment reaction time. The results of characterization studies on ZQDs revealed that particles are in monoclinic and tetragonal phase with the small spherical shape exhibiting blue–green and orange red emission properties. Electrochemical impedance and cyclic voltammetry studies were carried out, resulting in good electrocatalytic activity of ZQDs. Cellular mitochondrial activity was determined by MTT assay, anti-oxidant capability was determined using DPPH assay and in-vitro antibacterial activity studies were performed on Gram-negative E. coli bacteria and Gram-positive bacteria Bacillus subtilis for ZQDs. Biological studies on ZQDs revealed Ultrasonic 10 min (US-10) as a potential anti cancer agent against human cancer cell line (MCF-7) with an IC 50 value of 59.70 µg/mL, anti-oxidant agent with IC 50 value of 170 µg/mL and antibacterial agent showing good inhibition zones against E. coli and B. subtilis.
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Acknowledgements
The Authors are grateful to DST-Inspire (AORC) Fellowship for providing financial assistance. Also Authors acknowledge Prof. K. Girija, Department of Chemistry, Palamuru University for Encouragement and National Dong Hwa University, Taiwan for providing FESEM characterization.
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Reddy, G.D., Noorjahan, M., Ratnamala, A. et al. Electrochemical characterization and biological applications of luminescent zirconia quantum dots. Appl. Phys. A 126, 745 (2020). https://doi.org/10.1007/s00339-020-03942-3
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DOI: https://doi.org/10.1007/s00339-020-03942-3