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Tumour volume of resectable oesophageal squamous cell carcinoma measured with MRI correlates well with T category and lymphatic metastasis

  • Gastrointestinal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To determine association of gross tumour volume (GTV) of resectable oesophageal squamous cell carcinoma (SCC) measured on T2-weighted imaging (T2WI), contrast-enhanced T1-weighted imaging (CE-T1WI) and diffusion-weighted imaging (DWI) with T category and lymphatic metastasis (LM).

Methods

Sixty oesophageal SCC patients underwent fat-suppressed T2WI, CE-T1WI and DWI with b values of 0, 500 and 800 s/mm2. GTV was measured on three sequences. Statistical analyses were performed to determine association of GTV with T category and LM.

Results

Spearman's rank correlation analysis showed positive association of GTV with T category and LM (all p values < 0.01). Differences in GTV were found between T1 and T2 or T3 categories shown by Kruskal-Wallis H and one-way ANOVA tests, and between T1/T2 and T3 and between tumours with and without LM by Mann-Whitney U tests (all p values < 0.05). Receiver operating characteristic analyses showed cut-off GTVs of 5.795, 5.276 and 10.11 cm3 on CE-T1WI could better differentiate T1 from T2 categories, T1 from T3, and T1-2 from T3 than those of 7.066, 7.045 and 8.504 cm3 on T2WI, of 5.793, 6.609 and 6.989 cm3 on DWI with b value of 500 s/mm2, and of 4.156, 4.519 and 4.985 cm3 with b value of 800 s/mm2, respectively. Cut-off of 10.462 cm3 on DWI with b value of 500 s/mm2 could better identify LM than of 12.38, 8.793 and 9.600 cm3 on T2WI, CE-T1WI and DWI with b value of 800 s/mm2, respectively.

Conclusions

GTVs on T2WI, CE-T1WI and DWI are associated with T category of and LM of oesophageal SCC.

Key Points

• GTV is associated with T category and lymphatic metastasis of oesophageal SCC

• GTV measured on contrast-enhanced T 1 -weighted imaging better identifies T category

• GTV measured on DWI with b value of 500 s/mm 2 better identifies lymphatic metastasis

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Abbreviations

EUS:

Endoscopic ultrasonography

GTV:

Gross tumour volume

ICC:

Intraclass correlation coefficient

LAVA:

Liver acquisition with volume acceleration

LM:

Lymphatic metastasis

SCC:

Squamous cell carcinoma

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Funding

This study has received funding by the National Natural Science Foundation of China (grant no. 81571645), the Sichuan Province Special Project for Youth Team of Science and Technology Innovation (grant no. 2015TD0029), and the Construction Plan for Scientific Research Team of Sichuan Provincial Colleges and Universities (grant no. 15TD0023).

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Authors and Affiliations

  1. Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 63# Wenhua Road, Shunqing District, Nanchong, 637000, Sichuan, China

    Lan Wu, Jing Ou, Tian-wu Chen, Rui Li, Xiao-ming Zhang, Yan-li Chen, Yu Jiang, Jian-qiong Yang & Jin-ming Cao

Authors
  1. Lan Wu
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  2. Jing Ou
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  6. Yan-li Chen
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  7. Yu Jiang
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Corresponding author

Correspondence to Tian-wu Chen.

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Guarantor

The scientific guarantor of this publication is Tian-wu Chen from the Department of Radiology, Affiliated Hospital of North Sichuan Medical College.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• diagnostic or prognostic study

• performed at one institution

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Wu, L., Ou, J., Chen, Tw. et al. Tumour volume of resectable oesophageal squamous cell carcinoma measured with MRI correlates well with T category and lymphatic metastasis. Eur Radiol 28, 4757–4765 (2018). https://doi.org/10.1007/s00330-018-5477-0

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  • DOI: https://doi.org/10.1007/s00330-018-5477-0

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