Abstract
This Editorial Comment refers to the articles “Diagnostic evaluation of magnetization transfer and diffusion kurtosis imaging for prostate cancer detection in a re-biopsy population” by Barrett T et al., Eur Radiol. 2017 Dec 8 and “18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients” by Selnæs KM et al., Eur Radiol. 2018 Jan 2.
Prostate cancer (PCa) is the most common cancer in men. Although many of these tumours may be indolent and do not require treatment, prostate cancer is the third cause of mortality in Europe and the USA. Recent advances in management of PCa have become possible with improved staging and restaging, with multimodality imaging being instrumental. A rapid survey of recent issues of European Radiology confirms the vitality of the clinical research in modern non-invasive imaging of prostate cancer.
Advances in MRI
MRI plays an important role in the clinical imaging evaluation of the prostate gland. Prostate MRI is recommended for the local staging by EAU guidelines for intermediate- and high-risk prostate cancer [1]. The diagnosis of prostate cancer differs from that in other solid organs where imaging is used to identify those patients who require biopsy. Many men without prostate cancer undergo unnecessary biopsies, clinically insignificant cancers are often detected and clinically significant cancers are missed. The introduction of pre-biopsy MRI as a triage test could potentially minimise unnecessary detection of clinically insignificant disease while improving the identification of clinically relevant disease. With a very high negative predictive value [2], approaching 90%, MRI combining T2, perfusion (DCE) and diffusion-weighted (DW) imaging is now discussed before the first biopsy and validated before a re-biopsy [1]. MRI-targeted biopsy, using cognitive or software-based fusion of prostate MRI and real-time ultrasound (US) images, increases the detection of clinically significant PCa using fewer cores than standard biopsy [3].
MRI provides information, beyond anatomy (T2W), on tissue characteristics such as prostate volume, cellularity and vascularity with DCE and DW. It is now appreciated that most clinically relevant solid tumours are highly heterogeneous at the phenotypic, physiological and genomic levels and that they continue to evolve over time. This highlights the need for improvement of existing acquisition sequences, or development of additional functional sequences in order to find new biomarkers. In their study, Barrett et al. [4] evaluate two additional functional sequences, diffusion kurtosis imaging (DKI) and magnetisation transfer imaging (MTI) for prostate cancer detection. These techniques evaluate the heterogeneity of water diffusion and the structural integrity of tissues and microstructural changes induced by pathological processes. The authors found that those techniques were able to differentiate benign tissue from tumour, which is the first triage step to decide whether the patient should or should not undergo a re-biopsy. However, none of the measured parameters reliably differentiated low-grade from high-grade disease, whereas the prognosis is completely different. Accurate classification of the different Gleason score patterns on MRI is still a challenge and requires objective, reproducible, quantitative analysis methods. Texture analysis, which is a promising technique, could potentially distinguish between these different PCa patterns [5].
Advances in PET
Positron emission tomography (PET) has become the leading modality of nuclear medicine functional and molecular imaging compared to scintigraphy, due to superior image resolution, shorter waiting and image acquisition times, for a similar radiation exposure and a major player for PCa. A PubMed search for ‘prostate PET’ retrieved two articles on this topic in 1997, 62 in 2007 and 510 in 2017.
Radiolabeled 11C-choline or its fluorinated analogues have for over a decade been the reference PET radiotracers for PCa detection, especially in case of occult recurrence [6]. They are effective in detecting metastases in the skeleton, in distant lymph nodes and in the viscera [7]. Conversely, these tracers lack sensitivity in detecting small locoregional lymph node metastases and specificity in characterising lesions in the prostate bed. The radioligands of prostate-specific membrane antigen (PSMA) or of gastrin-releasing peptide receptor (GRPR) and 18F-fluciclovine, an amino-acid analogue, are currently in the forefront of innovative radiopharmaceuticals for PET. They are meant to not only detect metastatic PCa but also delineate PCa inside the prostate bed and in locoregional lymph nodes.
PSMA is a transmembrane type II glycoprotein, which is expressed by almost all PAs, either in primary tumours or metastases [8]. The diagnostic performance of PET imaging, using ligands of PSMA labelled with gallium-68 or more recently fluorine-18 in a PCa workup (initial staging and recurrence) has been reported in several concordant studies to be superior to that of radiolabeled 11C-choline or its fluorinated analogues [9, 10]. Compared with the radioligands of PSMA, the regulatory status of the amino-acid analogue 18F-fluciclovine, which has been developed in the USA, is quite different [11]. It is currently registered in the USA and EU, even though the published data about comparison with PET choline are currently limited to one study with 11C-choline [12] but none with 18F-fluorocholine. Only one short series of ten patients comparing 18F-fluciclovine and the ligand 68Ga-PSMA-11 has been published to date, suggesting a superior detection rate of 68Ga-PSMA-11 PET/CT compared to 18F-fluciclovine PET/CT in recurrent PCa [13]. Bombesin analogue antagonists of the GRPR labelled with radionuclides for PET are also entering evaluation in humans, showing favourable results compared to a choline analogue in preliminary studies [14]. A preliminary clinical series in PCa of PET/CT with radiotracer combining ligands of integrin αvβ3 and gastrin-releasing peptide receptor reported better results than with a radioligand binding to GRPR alone [15]. One major goal of this blossoming clinical research on PET radiotracers is the theranostic approach to select, based on PET, those patients who will be eligible for targeted radiotherapy using the same tracer labelled with a radionuclide designed for the destruction of tumours and of invisible spread [16, 17].
Evidence concerning all those flourishing tracers and imaging procedures is pending the results of ongoing prospective trials.
PET/MRI and complementarity
Combining the unique functional and/or biological information provided by PET with the performance of morphological imaging techniques, such as computed tomography (CT) or magnetic resonance imaging (MRI), is currently evidence for optimising the detection and identification of lesions and impact on patient care, especially in oncology.
PET/MRI, the most recent hybrid-imaging technology, appears to be particularly suited for the analysis of the prostate gland. Some authors have found that simultaneous PET/MRI using a radiolabelled PSMA ligand improved the diagnostic accuracy for PCa localisation compared to PET and multiparametric MRI considered separately [18].
Indeed, PET/MRI combines a multiparametric MRI with the molecular approach of PET imaging, which can pinpoint and characterise subcentimetre lesions. It has been recently demonstrated that textural analysis may assist in PCa detection in the transition zone on multiparametric MRI [19] and on PET/MRI using a PSMA ligand radiolabelled with gallium-68 [20].
Nevertheless, considering on the one hand the very high number of patients with PCa, and on the other the foreseeable limited availability of these machines, it is likely that MRI and PET will in most cases be performed separately. This stresses the importance of comparing the relative input of each examination for specific clinical questions like early detection of significant PCa, selection of cases for biopsy or re-biopsy, initial staging and detection of recurrences.
In addition, the development of radiomics is finding a fertile ground in the field of PCa. The disease is common, and most patients undergo iterative MRI, and PET examinations for detection, staging, surveillance, restaging and assessment of treatment efficacy, building an unprecedented large source of data for the elaboration of radiomics. Image interpretation for all these studies will potentially benefit from radiomics, as will the definition of imaging strategies. Although we learn a lot each day from MRI and PET, even more remains to be discovered.
Abbreviations
- DKI:
-
Diffusion kurtosis imaging
- GRPR:
-
Gastrin-releasing peptide receptor
- MTI:
-
Magnetisation transfer imaging
- PCa:
-
Prostate cancer
- PSMA:
-
Prostate-specific membrane antigen
References
Mottet N, Bellmunt J, Bolla M et al (2017) EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, diagnosis, and local treatment with curative intent. Eur Urol 71:618–629
Ahmed HU, El-Shater Bosaily A, Brown LC et al (2017) Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study. Lancet 389:815–822
Pokorny MR, de Rooij M, Duncan E et al (2014) Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol 66:22–29
Barrett T, McLean M, Priest AN et al (2017) Diagnostic evaluation of magnetization transfer and diffusion kurtosis imaging for prostate cancer detection in a re-biopsy population. Eur Radiol [Epub]
Nketiah G, Elschot M, Kim E et al (2017) T2-weighted MRI-derived textural features reflect prostate cancer aggressiveness: preliminary results. Eur Radiol 27:3050–3059
Kwee SA, DeGrado TR, Talbot JN et al (2007) Cancer imaging with fluorine-18-labeled choline derivatives. Semin Nucl Med. 37(6):420–428
Balogova S, Zakoun JB, Michaud L et al (2014) Whole-body 18F-fluorocholine (FCH) PET/CT and MRI of the spine for monitoring patients with castration-resistant prostate cancer metastatic to bone: a pilot study. Clin Nucl Med. 39(11):951–959
Mannweiler S, Amersdorfer P, Trajanoski S et al (2009) Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis. Pathol Oncol Res POR 15:167–172
Schwenck J, Rempp H, Reischl G et al (2017) Comparison of 68Ga-labelled PSMA-11 and 11C-choline in the detection of prostate cancer metastases by PET/CT. Eur J Nucl Med Mol Imaging 44:92–101
Gauthé M, Belissant O, Girard A et al (2017) TEP/TDM et récidive biologique d’adénocarcinome prostatique : apport du 68Ga-PSMA-11 lorsque la 18F-fluorocholine n’est pas contributive. Prog Urol 27:474–481
Selnæs KM, Krüger-Stokke B, Elschot M et al (2018) 18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients. Eur Radiol [Epub]
Nanni C, Zanoni L, Pultrone C et al (2016) (18)F-FACBC (anti1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid) versus (11)C-choline PET/CT in prostate cancer relapse: results of a prospective trial. Eur J Nucl Med Mol Imaging 43:1601–1610
Calais J, Fendler WP, Herrmann K et al (2017) Head-to-head comparison of 68Ga-PSMA-11 PET/CT and 18F-Fluciclovine PET/CT in a case series of 10 patients with prostate cancer recurrence. J Nucl Med [Epub]
Wieser G, Popp I, Christian Rischke H et al (2017) Diagnosis of recurrent prostate cancer with PET/CT imaging using the gastrin-releasing peptide receptor antagonist 68Ga-RM2: Preliminary results in patients with negative or inconclusive [18F]Fluoroethylcholine-PET/CT. Eur J Nucl Med Mol Imaging 44:1463–1472
Zhang J, Niu G, Lang L et al (2017) Clinical translation of a dual integrin αvβ3- and gastrin-releasing peptide receptor-targeting PET radiotracer, 68Ga-BBN-RGD. J Nucl Med 58:228–234
Maina T, Nock BA, Kulkarni H et al (2017) Theranostic prospects of gastrin-releasing peptide receptor-radioantagonists in oncology. PET Clin 12:297–309
Virgolini I, Decristoforo C, Haug A, et al (2017) Current status of theranostics in prostate cancer. Eur J Nucl Med Mol Imaging
Eiber M, Weirich G, Holzapfel K et al (2016) Simultaneous 68Ga-PSMA HBED-CC PET/MRI improves the localization of primary prostate cancer. Eur Urol 70:829–836
Sidhu HS, Benigno S, Ganeshan B et al (2017) Textural analysis of multiparametric MRI detects transition zone prostate cancer. Eur Radiol 27:2348–2358
Bates A, Miles K (2017) Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer. Eur Radiol 27:5290–5298
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The scientific guarantor of this publication is Jean-Noël Talbot (jean-noel.talbot@aphp.fr)
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This comment refers to the articles available at https://doi.org/10.1007/s00330-017-5169-1 and https://doi.org/10.1007/s00330-017-5213-1.
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Renard-Penna, R., Gauthé, M. & Talbot, JN. Editorial Comment: Advances in MRI and PET of the prostate: concurrence or complementarity?. Eur Radiol 28, 3138–3140 (2018). https://doi.org/10.1007/s00330-018-5459-2
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DOI: https://doi.org/10.1007/s00330-018-5459-2