Abstract
Objective
To determine the diagnostic accuracy of abdominal CT with compression to the right lower quadrant (RLQ) in adults with acute appendicitis.
Methods
168 patients (age range, 18–78 years) were included who underwent contrast-enhanced CT for suspected appendicitis performed either using compression to the RLQ (n = 71) or a standard protocol (n = 97). Outer diameter of the appendix, appendiceal wall thickening, luminal content and associated findings were evaluated in each patient. Kruskal-Wallis, Fisher’s and Pearson's chi-squared tests were used for statistical analysis.
Results
There was no significant difference in the mean outer diameter (MOD) between compression CT scans (10.6 ± 1.9 mm) and standard protocol (11.2 ± 2.3 mm) in patients with acute appendicitis (P = 1). MOD was significantly lower in the compression group (5.2 ± 0.8 mm) compared to the standard protocol (6.5 ± 1.1 mm) (P < 0.01) in patients without appendicitis. A cut-off value of 6.75 mm for the outer diameter of the appendix was found to be 100% sensitive in the diagnosis of acute appendicitis for both groups. The specificity was higher for compression CT technique (67.7 vs. 94.9%).
Conclusion
Normal appendix diameter was significantly smaller in the compression-CT group compared to standard-CT group, increasing diagnostic accuracy of abdominal compression CT.
Key points
• Normal appendix diameter is significantly smaller in compression CT.
• Compression could force contrast material to flow through the appendiceal lumen.
• Compression CT may be a CT counterpart of graded compression US.
Similar content being viewed by others
Abbreviations
- AA:
-
Acute appendicitis
- AUC:
-
Area under the curve
- CT:
-
Computed tomography
- EC:
-
External compression
- eGFR:
-
Estimated glomerular filtration rate
- RLQ:
-
Right lower quadrant
- ROC:
-
Receiver operating characteristics
- SB:
-
Saline bag
- SD:
-
Standard deviation
- US:
-
Ultrasonography
References
Jeffrey RB Jr, Laing FC, Townsend RR (1988) Acute appendicitis: sonographic criteria based on 250 cases. Radiology 167:327–329
Lane MJ, Liu DM, Huynh MD, Jeffrey RB Jr, Mindelzun RE, Katz DS (1999) Suspected acute appendicitis: nonenhanced helical CT in 300 consecutive patients. Radiology 213:341–346
Miki T, Ogata S, Uto M et al (2005) Enhanced multidetector-row computed tomography (MDCT) in the diagnosis of acute appendicitis and its severity. Radiat Med 23:242–255
Pickuth D, Spielmann RP (2001) Unenhanced spiral CT for evaluating acute appendicitis in daily routine. A prospective study. Hepatogastroenterology 48:140–142
Daly CP, Cohan RH, Francis IR, Caoili EM, Ellis JH, Nan B (2005) Incidence of acute appendicitis in patients with equivocal CT findings. AJR Am J Roentgenol 184:1813–1820
Karabulut N, Boyaci N, Yagci B, Herek D, Kiroglu Y (2007) Computed tomography evaluation of the normal appendix: comparison of low-dose and standard-dose unenhanced helical computed tomography. J Comput Assist Tomogr 31:732–740
Lai V, Chan WC, Lau HY, Yeung TW, Wong YC, Yuen MK (2012) Diagnostic power of various computed tomography signs in diagnosing acute appendicitis. Clin Imaging 36:29–34
Ives EP, Sung S, McCue P, Durrani H, Halpern EJ (2008) Independent predictors of acute appendicitis on CT with pathologic correlation. Acad Radiol 15:996–1003
Rettenbacher T, Hollerweger A, Macheiner P et al (2003) Ovoid shape of the vermiform appendix: a criterion to exclude acute appendicitis--evaluation with US. Radiology 226:95–100
Atema JJ, Gans SL, Van Randen A et al (2015) Comparison of ımaging strategies with conditional versus ımmediate contrast-enhanced computed tomography in patients with clinical suspicion of acute appendicitis. Eur Radiol 25:2445–2452
O'Malley ME, Alharbi F, Chawla TP, Moshonov H (2016) CT following US for possible appendicitis: anatomic coverage. Eur Radiol 26:532–538
Kammerer S, Hoink AJ, Wessling J et al (2015) Abdominal and pelvic CT: is positive enteric contrast still necessary? Results of a retrospective observational study. Eur Radiol 25:669–678
Puylaert JB (1986) Acute appendicitis: US evaluation using graded compression. Radiology 158:355–360
Stewart JK, Olcott EW, Jeffrey RB (2012) Sonography for appendicitis: nonvisualization of the appendix is an indication for active clinical observation rather than direct referral for computed tomography. J Clin Ultrasound 40:455–461
Webb EM, Wang ZJ, Coakley FV, Poder L, Westphalen AC, Yeh BM (2010) The equivocal appendix at CT: prevalence in a control population. Emerg Radiol 17:57–61
Tamburrini S, Brunetti A, Brown M, Sirlin CB, Casola G (2005) CT appearance of the normal appendix in adults. Eur Radiol 15:2096–2103
Benjaminov O, Atri M, Hamilton P, Rappaport D (2002) Frequency of visualization and thickness of normal appendix at nonenhanced helical CT. Radiology 225:400–406
Bursali A, Arac M, Oner AY, Celik H, Eksioglu S, Gumus T (2005) Evaluation of the normal appendix at low-dose non-enhanced spiral CT. Diagn Interv Radiol 11:45–50
Johnson PT, Eng J, Moore CJ, Horton KM, Fishman EK (2006) Multidetector-row CT of the appendix in healthy adults. Emerg Radiol 12:248–253
Charoensak A, Pongpornsup S, Suthikeeree W (2010) Wall thickness and outer diameter of the normal appendix in adults using 64 slices multidetector CT. J Med Assoc Thai 93:1437–1442
Cabarrus M, Sun YL, Courtier JL, Stengel JW, Coakley FV, Webb EM (2013) The prevalence and patterns of intraluminal air in acute appendicitis at CT. Emerg Radiol 20:51–56
Acknowledgements
The authors thank Assos. Prof. Erdem Karabulut, Phd (Department of Biostatistics, Hacettepe University, School of Medicine) for his help with the statistical analysis.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Guarantor
The scientific guarantor of this publication is Prof. Erhan Akpınar, MD.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Funding
The authors state that this work has not received any funding.
Statistics and biometry
Assos. Prof. Erdem Karabulut, Phd (Department of Biostatistics, Hacettepe University, School of Medicine) kindly provided statistical advice for this manuscript.
Ethical approval
Institutional Review Board approval was obtained.
Informed consent
Written informed consent was obtained from all patients in this study.
Study subjects or cohorts overlap
Some study subjects or cohorts have been previously reported in the annual meeting of RSNA in 2014.
Methodology
• prospective
• diagnostic study
• performed at one institution
Rights and permissions
About this article
Cite this article
Kılınçer, A., Akpınar, E., Erbil, B. et al. A new technique for the diagnosis of acute appendicitis: abdominal CT with compression to the right lower quadrant. Eur Radiol 27, 3317–3325 (2017). https://doi.org/10.1007/s00330-016-4728-1
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-016-4728-1