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Safety and efficacy of multilevel vertebroplasty for painful osteolytic spinal metastases: a single-centre experience

  • Musculoskeletal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objective

To retrospectively assess the safety and efficacy of percutaneous vertebroplasty (PVP) for painful osteolytic spinal metastases when treating more than three vertebrae per session.

Methods

A total of 153 patients with painful osteolytic spinal metastases underwent PVP. Group A patients (n = 93) underwent PVP at up to three vertebral levels per session. Group B patients (n = 60) underwent PVP at more than three levels in one session. Pain, quality of life (QoL), and mobility were assessed before and after PVP. Minor and major complications were systematically assessed.

Results

Both groups experienced significant pain relief and QoL improvement after the intervention (p < 0.001). Mobility improvement was observed in both groups, despite worse mobility status before PVP in group B compared with group A. There was no significant difference between the two groups throughout the follow-up period in overall pain relief and improvement in QoL and mobility. There was also no significant difference between groups in minor and major complications.

Conclusions

Multilevel vertebroplasty is safe and effective for the treatment of multiple osteolytic spinal metastases. Multilevel PVP relieves pain and improves QoL and mobility.

Key Points

• Percutaneous vertebroplasty is safe and effective for painful osteolytic spinal metastases.

• Multilevel vertebroplasty does not cause more complications than single-level vertebroplasty.

• Multiple spinal metastases patients may regain functional independence after multilevel vertebroplasty.

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Abbreviations

QoL:

Quality of life

PVP:

Percutaneous vertebroplasty

PMMA:

Polymethyl methacrylate

VAS:

Visual analogue scale

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Acknowledgements

The scientific guarantor of this publication is Yang Yao. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the National Natural Science Foundation of China (81503396) and Shanghai Xinglinxinxing Program (ZY3-RCPY-2-2035). No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the IRB. Methodology: retrospective, case-control study, performed at one institution.

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    Authors and Affiliations

    1. Department of Internal Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Rd, Shanghai, 200233, China

      Jian-Jun Zhang, Yan Zhou, Hai-Yan Hu, Yuan-Jue Sun, Yong-Gang Wang, Yi-Feng Gu, Chun-Gen Wu, Zan Shen & Yang Yao

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    1. Jian-Jun Zhang
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    2. Yan Zhou
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    Correspondence to Yang Yao.

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    Jian-Jun Zhang and Yan Zhou contributed equally to this work.

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    Zhang, JJ., Zhou, Y., Hu, HY. et al. Safety and efficacy of multilevel vertebroplasty for painful osteolytic spinal metastases: a single-centre experience. Eur Radiol 27, 3436–3442 (2017). https://doi.org/10.1007/s00330-016-4683-x

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