Abstract
Objectives
To compare Gd-EOB-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.
Methods
Fourteen patients underwent Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T max, T 1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.
Results
Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r 2 = 0.802, p = 0.001) and RE for LLL (r 2 = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r 2 = 0.560, p = 0.037) and RE for RLL (r 2 = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r 2 = 0.775, p = 0.002).
Conclusions
Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.
Key points
• Information about liver function can be acquired with routine Gd-EOB-MRI.
• Gd-EOB-MRI and 99m Tc-mebrofenin HBS show elevated function of non-embolized lobe.
• Gd-EOB-MRI and 99m Tc-mebrofenin HBS can determine lobar liver function.
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Abbreviations
- FRL:
-
future remnant liver
- Gd-EOB-DTPA:
-
gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid
- HBS:
-
hepatobiliary scintigraphy
- HUI:
-
hepatic uptake index
- ICG:
-
indocyanine green
- LLL:
-
left liver lobe
- PVE:
-
portal vein embolization
- RE:
-
relative enhancement
- RLL:
-
right liver lobe
- ROI:
-
region of interest
- SI:
-
signal intensity
- VIBE:
-
volume interpolated breath-hold examination
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Acknowledgments
The scientific guarantor of this publication is Dominik Geisel. The authors of this manuscript declare relationships with the following companies: Bayer AG. The authors state that this work has not received any funding. One of the authors has significant statistical expertise. Institutional review board approval was obtained. Written informed consent was waived by the institutional review board. Methodology: retrospective, diagnostic or prognostic study, performed at one institution.
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Geisel, D., Lüdemann, L., Fröling, V. et al. Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI. Eur Radiol 25, 1384–1391 (2015). https://doi.org/10.1007/s00330-014-3536-8
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DOI: https://doi.org/10.1007/s00330-014-3536-8