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Regulatory roles of selective autophagy through targeting of native proteins in plant adaptive responses

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Abstract

Key message

Selective autophagy functions as a regulatory mechanism by targeting native and functional proteins to ensure their proper levels and activities in plant adaptive responses.

Abstract

Autophagy is a cellular degradation and recycling pathway with a key role in cellular homeostasis and metabolism. Autophagy is initiated with the biogenesis of autophagosomes, which fuse with the lysosomes or vacuoles to release their contents for degradation. Under nutrient starvation or other adverse environmental conditions, autophagy usually targets unwanted or damaged proteins, organelles and other cellular components for degradation and recycling to promote cell survival. Over the past decade, however, a substantial number of studies have reported that autophagy in plants also functions as a regulatory mechanism by targeting enzymes, structural and regulatory proteins that are not necessarily damaged or dysfunctional to ensure their proper abundance and function to facilitate cellular changes required for response to endogenous and environmental conditions. During plant-pathogen interactions in particular, selective autophagy targets specific pathogen components as a defense mechanism and pathogens also utilize autophagy to target functional host factors to suppress defense mechanisms. Autophagy also targets native and functional protein regulators of plant heat stress memory, hormone signaling, and vesicle trafficking associated with plant responses to abiotic and other conditions. In this review, we discuss advances in the regulatory roles of selective autophagy through targeting of native proteins in plant adaptive responses, what questions remain and how further progress in the analysis of these special regulatory roles of autophagy can help understand biological processes important to plants.

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Funding

This research was supported by Zhejiang Provincial Natural Science Foundation of China under Grant No. LY22C150007, the Key Research and Development Program of Lishui under Grant No. 2020ZDYF08 and Lishui University Initial Funding under Grant No. QD1503.

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Authors and Affiliations

  1. Department of Landscape and Horticulture, Ecology College, Lishui University, Lishui, Zhejiang, China

    Yan Zhang, Gengshou Xia, Li Sheng, Mingjue Chen, Chenyang Hu, Yule Ye, Xiaoyan Yue, Shaocong Chen & Wenwu OuYang

  2. China Medical University -The Queen’s University of Belfast Joint College, China Medical University, Shenyang, Liaoning, China

    Zhenkai Xia

Authors
  1. Yan Zhang
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  2. Gengshou Xia
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  3. Li Sheng
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  4. Mingjue Chen
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  5. Chenyang Hu
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  6. Yule Ye
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  7. Xiaoyan Yue
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  8. Shaocong Chen
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  9. Wenwu OuYang
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  10. Zhenkai Xia
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Contributions

YZ conceived the idea. YZ, GSX, LS, MJC, CYH, YLY, XYY, SCC, WWOY and ZKX wrote and evaluated the manuscript.

Corresponding author

Correspondence to Yan Zhang.

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Conflict of interests

The authors declare no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.

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Communicated by Wusheng Liu.

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Zhang, Y., Xia, G., Sheng, L. et al. Regulatory roles of selective autophagy through targeting of native proteins in plant adaptive responses. Plant Cell Rep 41, 2125–2138 (2022). https://doi.org/10.1007/s00299-022-02910-w

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