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Ca2+–CBL–CIPK: a modulator system for efficient nutrient acquisition

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Abstract

Calcium (Ca2+) is a universal second messenger essential for the growth and development of plants in normal and stress situations. In plants, the proteins, CBL (calcineurin B-like) and CIPK (CBL-interacting protein kinase), form one of the important Ca2+ decoding complexes to decipher Ca2+ signals elicited by environmental challenges. Multiple interactors distinguish CBL and CIPK protein family members to form a signaling network for regulated perception and transduction of environmental signals, e.g., signals generated under nutrient stress conditions. Conservation of equilibrium in response to varying soil nutrient status is an important aspect for plant vigor and yield. Signaling processes have been reported to observe nutrient fluctuations as a signal responsible for regulated nutrient transport adaptation. Recent studies have identified downstream targets of CBL–CIPK modules as ion channels or transporters and their association in signaling nutrient disposal including potassium, nitrate, ammonium, magnesium, zinc, boron, and iron. Ca2+–CBL–CIPK pathway modulates ion transporters/channels and hence maintains a homeostasis of several important plant nutrients in the cytosol and sub-cellular compartments. In this article, we summarize recent literature to discuss the role of the Ca2+–CBL–CIPK pathway in cellular osmoregulation and homeostasis on exposure to nutrient excess or deprived soils. This further establishes a link between taking up the nutrient in the roots and its distribution and homeostasis during the generation of signal for the development and survival of plants.

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Acknowledgements

Research work in our lab is supported by Delhi University (IoE/FRP grant), Board of Research in Nuclear Sciences (BRNS), Department of Biotechnology (DBT), Science and Engineering Research Board (SERB), Council for Scientific and Industrial Research (CSIR), India. PV is thankful to CSIR, India for CSIR-SRA fellowship.

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  1. Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi, 110021, India

    Pooja Verma, Sibaji K. Sanyal & Girdhar K. Pandey

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  1. Pooja Verma
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  2. Sibaji K. Sanyal
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  3. Girdhar K. Pandey
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GKP conceived the review. PV, SKS, and GKP wrote and revised the manuscript.

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Correspondence to Girdhar K. Pandey.

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Verma, P., Sanyal, S.K. & Pandey, G.K. Ca2+–CBL–CIPK: a modulator system for efficient nutrient acquisition. Plant Cell Rep 40, 2111–2122 (2021). https://doi.org/10.1007/s00299-021-02772-8

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