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Anxiety and depression in reproductive age women with rheumatic diseases

  • Observational Research
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Abstract

Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in women in reproductive age. We conducted an observational, single-center, cross-sectional, and descriptive study in reproductive-age, non-pregnant women without a prior psychiatric diagnosis. Differences between disease groups, subscale results, and disease activity were analyzed with the Chi square, Mann–Whitney U test, or Kruskal–Wallis test. A total of 100 women were included. Mean age was 35.3 years (SD = 10.07). The most frequent diagnosis was rheumatoid arthritis (RA) with 48, followed by systemic lupus erythematosus (SLE) with 30. A total of 66 (66%) patients had an abnormal HADS score (probable or possible cases) in either subscale. More than 50% of RA patients had an abnormal HADS score. We found an association between RA disease activity groups and total HADS score (p = 0.003). Furthermore, we found a statically significant association between RA activity groups and HADS anxiety subscales group classification (p = 0.01). No differences between disease activity groups of SLE or other diseases and HADS classification or total score was found (p = 0.277). A high frequency of probable or possible cases of depression and anxiety were recognized in reproductive-age women with RD. A high RA disease activity was associated with a high total HADS score and an increased presence of anxiety symptoms.

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Acknowledgements

We thank Dr. Sergio Lozano-Rodriguez for his help in reviewing and editing the manuscript.

Funding

No funding was received for this protocol.

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Authors and Affiliations

  1. Rheumatology Service, Hospital Universitario “Dr. José Eleuterio Gonzalez”, Universidad Autónoma de Nuevo León, Av. Gonzalitos 235 Norte, Colonia Mitras Centro, C.P 64460, Monterrey, Nuevo León, Mexico

    Cassandra Michele Skinner-Taylor, Lorena Perez-Barbosa, Maria Eugenia Corral-Trujillo, Itzel Perez-Onofre, Eugenio Salvador Barriga-Maldonado, Jesus Alberto Cardenas-de la Garza, Janett Riega-Torres & Dionicio Angel Galarza-Delgado

Authors
  1. Cassandra Michele Skinner-Taylor
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  2. Lorena Perez-Barbosa
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  3. Maria Eugenia Corral-Trujillo
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  4. Itzel Perez-Onofre
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  5. Eugenio Salvador Barriga-Maldonado
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  6. Jesus Alberto Cardenas-de la Garza
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  7. Janett Riega-Torres
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  8. Dionicio Angel Galarza-Delgado
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Contributions

Cassandra Michele Skinner-Taylor, Lorena Pérez-Barbosa and Maria Eugenia Corral-Trujillo, contributed to the study conception and design. Recruitment was performed by Eugenio Salvador Barriga-Maldonado, Itzel Perez-Onofre and Maria Eugenia Corral-Trujillo. Statiscal analyses were performed by Jesus Alberto Cardenas-de la Garza. Analysis and interpretations were performed by Cassandra Michele Skinner-Taylor, Lorena Pérez-Barbosa, Janett Riega-Torres and Dionicio Angel Galarza-Delgado. Writing of the first draft was performed by Jesus Alberto Cardenas-de la Garza and Eugenio Salvador Barriga-Maldonado, Janett Riega-Torres. All authors commented on posterior versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Lorena Perez-Barbosa.

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Conflicts of interest

None of the authors of this study has any financial interest or conflict with industries or parties.

Ethics approval

The protocol was approved by the Ethics and Research Committee of the School of Medicine and University Hospital “Dr. José Eleuterio González” from the Universidad Autónoma de Nuevo León (RE18-00008).

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All the data retrieved were anonymized. Verbal informed consent was obtained prior to the interview.

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Conference abstracts: Skinner-Taylor, et al. Anxiety and Depression in a Pregnancy and Rheumatic Diseases. Ann Rheum Dis 78 (Suppl 2):694–695, 2019 (EULAR congress), FRI0067, DOI: http://dx.doi.org/10.1136/annrheumdis-2019-eular.7952.

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Skinner-Taylor, C.M., Perez-Barbosa, L., Corral-Trujillo, M.E. et al. Anxiety and depression in reproductive age women with rheumatic diseases. Rheumatol Int 40, 1433–1438 (2020). https://doi.org/10.1007/s00296-020-04591-8

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  • DOI: https://doi.org/10.1007/s00296-020-04591-8

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