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Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis

  • Genes and Disease
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Abstract

Rheumatoid arthritis is an autoimmune disease that affects several organs and tissues, predominantly the synovial joints. The pathogenesis of this disease is not completely understood, which maybe involved in the genomic variations, gene expression, protein translation and post-translational modifications. These system variations in genomics, transcriptomics and proteomics are dynamic in nature and their crosstalk is overwhelmingly complex, thus analyzing them separately may not be very informative. However, various ‘-omics’ techniques developed in recent years have opened up new possibilities for clarifying disease pathways and thereby facilitating early diagnosis and specific therapies. This review examines how recent advances in the fields of genomics, transcriptomics and proteomics have contributed to our understanding of rheumatoid arthritis.

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Abbreviations

RA:

Rheumatoid arthritis

FLS:

Fibroblast-like synovial cells

HC:

Healthy control

IFN:

Interferon

OA:

Osteoarthritis

PBMC:

Peripheral blood mononuclear cell

RASF:

Rheumatoid arthritis synovial fibroblast

RNAseq:

RNA sequencing

SF:

Synovial fibroblast

SPP1:

Secreted phosphoprotein 1

2DE:

Two-dimensional gel electrophoresis

2D-LC:

Two-dimensional liquid chromatography

DIGE:

Difference gel electrophoresis

iTRAQ:

Isobaric tagging for relative and absolute quantitation

LC–MS/MS:

Liquid chromatography coupled to tandem mass spectrometry

MALDI-TOF MS:

Matrix-assisted laser desorption ionization-time of-flight mass spectrometry

MSC:

Mesenchymal stem cell

SLE:

Systemic lupus erythematosus

SpA:

Spondyloarthropathy

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Acknowledgements

This research was supported by the China Scholarship Council and the International Training Program of High-Level Talents in Henan Province.

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  1. Department of Biological Sciences, Xinyang Normal University, Xinyang, 464000, China

    Xinqiang Song

  2. Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore

    Xinqiang Song & Qingsong Lin

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  1. Xinqiang Song
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Correspondence to Xinqiang Song or Qingsong Lin.

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Song, X., Lin, Q. Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis. Rheumatol Int 37, 1257–1265 (2017). https://doi.org/10.1007/s00296-017-3732-3

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