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Primary Sjögren’s syndrome and B-non-Hodgkin lymphoma: role of CD4+ T lymphocytopenia

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Abstract

Primary Sjögren’s syndrome (PSS) is associated with increased risk of lymphoproliferative malignancy, and B-cell non-Hodgkin lymphoma (B-NHL) is the most frequent type. To evaluate CD4+ T lymphocytes distributions in patients with (PSS) and the association of CD4+ T lymphocytopenia with the development of (B-NHL), this study included 8 (PSS) patients associated with B-NHL (group I), 50 (pSS) patients without B-NHL (group II), and 30 healthy volunteers who served as controls. The frequency of circulating CD4+ and CD8+ T lymphocytes distributions and CD4+/CD8+ T cell ratio was assessed using flow cytometry coulter EPICS-XL and compared between patients groups and controls. There was statistically significant CD4+ T lymphocytopenia in (PSS) patients with B-NHL than those without lymphoma and controls (P = 0.001). Moreover, a significant low CD4+/CD8+ T cell ratio 0.8 in group I than group II and controls (P = 0.001) was found. Significant positive correlations of CD4+ T lymphocytopenia with other risk factors (parotid swelling, vasculitis, rheumatoid factors, low complement, cryoglobulinemia) were detected. CD4+ T lymphocytopenia is associated with B-NHL developed in patients with PSS and can be considered as an important predictor of lymphoma.

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Notes

  1. Controls: 30 apparently healthy matched subjects were also included. Patients were recruited from oncology, rheumatology, ophthalomology, and internal medicine departments, at an interval of 6 years from December 2005 to December 2011. Patients and controls gave informed consent to participate in this study. Careful history taking and clinical examination including oral symptoms and signs, ocular symptoms and signs (Schirmer’s test), parotid enlargement, lip biopsy, lymphadenopathy, organomegaly (hepatomegaly and splenomegaly), arthritis, purpura, fibromyalgia, neuropathy and vasculitis were recorded.

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Authors and Affiliations

  1. Departments of Rheumatology and Rehabilitation, Faculty of Medicine, EL-Minia University, EL-Minia, Egypt

    Faten Ismail

  2. Department of Clinical Pathology, Faculty of Medicine, EL-Minia University, EL-Minia, Egypt

    Amel Mahmoud

  3. Department of Internal Medicine, Faculty of Medicine, EL-Minia University, EL-Minia, Egypt

    Hisham Abdelhaleem

  4. Department of Oncology, Faculty of Medicine, EL-Minia University, EL-Minia, Egypt

    Amro Mamdoh

  5. Department of Ophthalmology, Faculty of Medicine, EL-Minia University, EL-Minia, Egypt

    M. Geneidy

  6. Department of Tropical Medicine, Faculty of Medicine, EL-Minia University, EL-Minia, Egypt

    Enas Kamal

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  1. Faten Ismail
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  2. Amel Mahmoud
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  3. Hisham Abdelhaleem
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  4. Amro Mamdoh
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  5. M. Geneidy
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  6. Enas Kamal
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Correspondence to Faten Ismail.

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Ismail, F., Mahmoud, A., Abdelhaleem, H. et al. Primary Sjögren’s syndrome and B-non-Hodgkin lymphoma: role of CD4+ T lymphocytopenia. Rheumatol Int 33, 1021–1025 (2013). https://doi.org/10.1007/s00296-012-2464-7

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  • DOI: https://doi.org/10.1007/s00296-012-2464-7

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