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QT dispersion in amyloidosis due to familial Mediterranean fever

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Abstract

Cardiac amyloid deposition in FMF may cause increased QT dispersion (QTd), a marker for cardiac arrhythmias. The aim of this study was to further evaluate repolarization dispersion in familial Mediterranean fever (FMF) with amyloidosis. Findings on 12-lead electrocardiography were compared between 18 patients with FMF-amyloidosis and 18 age- and sex-matched control subjects. Repolarization and dispersion parameters were computed with designated computer software, and results of the 5 beats were subsequently averaged. There were no statistically significant differences between the groups as to average corrected QT interval length, average QTd interval, average QT corrected dispersion, or QT dispersion ratio. JT dispersion and JT corrected dispersion were also similar in both groups. In conclusion, patients with FMF-amyloidosis seem to have QT and JT dispersion parameters similar to those of healthy subjects. Future research and longer follow-ups should be conducted in order to evaluate the prognostic importance of repolarization dispersion parameters in amyloidosis of FMF.

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Acknowledgments

We thank Phyllis Curchack Kornspan for her editorial assistance. This study is dedicated to the memory of Haim Gueron.

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None.

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Authors and Affiliations

  1. The Heller Institute of Medical Research, and Department of Medicine F, Sheba Medical Center, Tel Hashomer Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Udi Nussinovitch, Olga Feld, Ilan Ben-Zvi & Avi Livneh

  2. Hypertension Unit and Department of Internal Medicine D, Sheba Medical Center, Tel Hashomer, Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Naomi Nussinovitch

  3. Department of Pediatrics C, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Moshe Nussinovitch & Benjamin Volovitz

Authors
  1. Udi Nussinovitch
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  2. Naomi Nussinovitch
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  3. Moshe Nussinovitch
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  4. Benjamin Volovitz
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  5. Olga Feld
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  6. Ilan Ben-Zvi
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  7. Avi Livneh
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Corresponding author

Correspondence to Udi Nussinovitch.

Additional information

Udi Nussinovitch and Naomi Nussinovitch contributed equally to this work.

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Nussinovitch, U., Nussinovitch, N., Nussinovitch, M. et al. QT dispersion in amyloidosis due to familial Mediterranean fever. Rheumatol Int 32, 1945–1948 (2012). https://doi.org/10.1007/s00296-011-1896-9

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  • DOI: https://doi.org/10.1007/s00296-011-1896-9

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