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Cardiovascular reactivity score for the assessment of dysautonomia in familial Mediterranean fever

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Abstract

Objective

The aim of this study was to assess the presence of dysautonomia, as manifested in abnormal cardiovascular reactivity, in patients with familial Mediterranean fever (FMF).

Methods

Fifty-five consecutive patients with FMF and 23 age- and sex-matched healthy controls were evaluated. Cardiovascular reactivity was studied: (1) using recordings of blood pressure (BP) and heart rate (HR) during 10 min of recumbence and 30 min of head-up tilt test to identify clinical endpoints and (2) during tilt-test, identifying parameters acting as independent predictors of FMF reactivity and enabling computation of a cardiovascular reactivity score (CVRS).

Results

Clinically, vasovagal reaction, postural tachycardia syndrome, and/or orthostatic hypotension were observed in ten patients (18.1%). Utilizing a derived equation, the group average CVRS in FMF was 5.83±1.78 (healthy group −7.60±5.41) (P=<0.0001). A CVRS of >3.25 was associated with FMF, with 98% sensitivity and 100% specificity.

Conclusion

A very high percentage of FMF patients exhibit abnormal cardiovascular reactivity which is clinically occult but can be detected on autonomic challenge and application of the CVRS.

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Authors and Affiliations

  1. Department of Rheumatology, Zevulun Clinic and Bnai Zion Medical Center, Bruce Rappaport Faculty of Medicine, Technion, POB 4940, Haifa 31048, Israel

    Michael Rozenbaum, Edmond Sabo & Itzhak Rosner

  2. Department of Internal Medicine A, Bnai Zion Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

    Jochanan E. Naschitz, Naomi Shaviv, Eli Zuckerman & Daniel Yeshurun

  3. Department of Anesthesiology, Bnai Zion Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

    Marina Yudashkin & Luis Gaitini

  4. Department of Pathology, Bnai Zion Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

    Edmond Sabo

  5. Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel

    Edmond Sabo

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  1. Michael Rozenbaum
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  2. Jochanan E. Naschitz
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  3. Marina Yudashkin
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  4. Edmond Sabo
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  5. Naomi Shaviv
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  6. Luis Gaitini
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  7. Eli Zuckerman
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  8. Daniel Yeshurun
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  9. Itzhak Rosner
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Correspondence to Michael Rozenbaum.

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Rozenbaum, M., Naschitz, J.E., Yudashkin, M. et al. Cardiovascular reactivity score for the assessment of dysautonomia in familial Mediterranean fever. Rheumatol Int 24, 147–152 (2004). https://doi.org/10.1007/s00296-003-0344-x

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  • DOI: https://doi.org/10.1007/s00296-003-0344-x

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