References
Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q, Chihara K (2002) Plasma lipids and osteoporosis in postmenopausal women. Endocr J 49:211–217
Sivas F, Alemdaroğlu E, Elverici E, Kuluğ T, Ozoran K (2009) Serum lipid profile: its relationship with osteoporotic vertebrae fractures and bone mineral density in Turkish postmenopausal women. Rheumatol Int 29:885–890
Parhami F (2003) Possible role of oxidized lipids in osteoporosis: could hyperlipidemia be a risk factor? Prostaglandins Leukot Essent Fatty Acids 68:373–378
Kohlmeier M, Saupe J, Schaefer K, Asmus G (1998) Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype. Calcif Tissue Int 62:278–281
Hak AE, Witteman JC, Hugens W, Keyzer JJ, Pop VJ, Uitterlinden AG, Pols HA (2004) The increase in cholesterol with menopause is associated with the apolipoprotein E genotype. A population-based longitudinal study. Atherosclerosis 175:169–176
Heikkinen AM, Niskanen L, Ryynänen M, Komulainen MH, Tuppurainen MT, Parviainen M, Saarikoski S (1999) Is the response of serum lipids and lipoproteins to postmenopausal hormone replacement therapy modified by ApoE genotype? Arterioscler Thromb Vasc Biol 19:402–407
Long JR, Zhao LJ, Liu PY et al (2004) Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. BMC Genetics 5:11–17
Ma L, Runesha HB, Dvorkin D, Garbe JR, Da Y (2008) Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide association studies. BMC Bioinformatics 9:315
He LN, Recker RR, Deng HW, Dvornyk V (2009) A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females. Maturitas 62:37–41
Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G, Puca AA (2008) Lack of replication of genetic associations with human longevity. Biogerontology 9:85–92
Martin ER, Lai EH, Gilbert JR et al (2000) SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum Genet 67:383–394
Acknowledgments
The project was funded by the DST, New Delhi under the grant (SR/WOS-A/LS-225/2007), which is highly acknowledged.
Conflict of interest statement
All the authors have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Singh, M., Singh, P., Juneja, P.K. et al. SNP–SNP interactions within APOE gene influence plasma lipids in postmenopausal osteoporosis. Rheumatol Int 31, 421–423 (2011). https://doi.org/10.1007/s00296-010-1449-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-010-1449-7