Abstract
Positioning the nucleus to a specific cellular location is a prerequisite for high-fidelity transmission of the genetic material to daughter cells. The cellular location of the nucleus just before its division is variable in budding yeast species which rely on a variety of mechanisms for nuclear division. Dynamic growth and shrinkage kinetics of microtubules (MTs) and forces exerted by the MT plus- and minus-end-directed motor proteins empower nuclear movement. Even though the overall process of nuclear migration is largely conserved across budding yeasts, in-depth molecular analyses of newly emerging model budding yeasts began to reveal striking differences from the paradigms that have been established based on the studies performed in the well-characterized budding yeast Saccharomyces cerevisiae. Here, we highlight the molecular players involved in differential nuclear migration in diverse budding yeasts.
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The U. maydis cartoons are adapted from Straube et al. 2005
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Acknowledgements
We thank members of the Molecular Mycology Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India for useful discussion and suggestions. We apologize to those whose work could not be mentioned because of space restrictions. This work was supported by Tata Innovation Fellowship ((BT/HRD/35/01/03/2017) and intramural support from JNCASR to KS and a research associate fellowship from the Council of Scientific and Industrial Research (CSIR) (09/733 (0253)/219-EMR-I) and (9/733 (0161)/2011-EMR-I) to NV.
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Varshney, N., Sanyal, K. Nuclear migration in budding yeasts: position before division. Curr Genet 65, 1341–1346 (2019). https://doi.org/10.1007/s00294-019-01000-x
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DOI: https://doi.org/10.1007/s00294-019-01000-x