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Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system

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Abstract

Quorum sensing (QS) plays critical roles in virulence gene expression and the pathogenesis of Pseudomonas aeruginosa, an important human pathogen. However, the regulatory effects, especially that occur directly upstream of the QS system, remain largely unknown. Here, we review recent advances in the understanding of the key component of carbon catabolite repression (CCR) system and protein quality control (PQC) system in regulating the QS system in P. aeruginosa. We propose that PQC proteases Lon and ClpXP may have an important role in linking CCR with QS, and thus contribute to the integration of nutritional cues into the regulatory network governing the virulence factors expression in P. aeruginosa.

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Acknowledgments

This work was supported by National Natural Science Foundation of China Grants (31270126) (to L.L) and Shanghai Committee of Science and Technology Grants (12JC1410200) (to L.L). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong Zhangjiang Hi-Tech Park, Shanghai, 201203, China

    Nana Yang & Lefu Lan

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  1. Nana Yang
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  2. Lefu Lan
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Correspondence to Lefu Lan.

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Communicated by M. Kupiec.

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Yang, N., Lan, L. Pseudomonas aeruginosa Lon and ClpXP proteases: roles in linking carbon catabolite repression system with quorum-sensing system. Curr Genet 62, 1–6 (2016). https://doi.org/10.1007/s00294-015-0499-5

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