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Vergleichende Pathologie in der onkologischen Forschung

Comparative pathology in oncology—Best practice

  • Schwerpunkt: Next Generation Pathology
  • Published:
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Zusammenfassung

Die vergleichende experimentelle Pathologie („comparative experimental pathology“) ist ein Fachbereich an der Schnittstelle von Human- und Veterinärmedizin. Sie widmet sich der vergleichenden Erforschung von Gemeinsamkeiten und Unterschieden von spontanen und experimentell induzierten Erkrankungen bei (Modell‑)Tieren mit Krankheiten des Menschen. Der Einsatz von Tiermodellen zur Erforschung menschlicher Erkrankungen ist ein essenzieller Bestandteil biomedizinischer Forschung. Interdisziplinäre Teams mit speziesspezifischer Expertise sollten, wo immer möglich, zusammenarbeiten und in regem Austausch stehen. Wechselseitige Offenheit, Kooperations- und Lernbereitschaft bilden hierbei die Basis für eine gewinnbringende Zusammenarbeit. Forschungsprojekte unter gemeinsamer Leitung bzw. Mitarbeit von Tier- und Humanpathologen leisten so einen wesentlichen Beitrag zu qualitativ hochwertiger biomedizinischer Forschung. Entsprechende Ansätze sind nicht nur (wie in diesem Artikel ausgeführt) in der onkologischen Forschung, sondern auch in weiteren Forschungsbereichen, in denen regelmäßig Tiermodelle angewandt werden (z. B. Infektiologie, Neurologie, Entwicklungsbiologie u. a.), Erfolg versprechend.

Abstract

Comparative experimental pathology is a research field at the interface of human and veterinary medicine. It is focused on the comparative study of similarities and differences between spontaneous and experimentally induced diseases in animals (animal models) compared to human diseases. The use of animal models for studying human diseases is an essential component of biomedical research. Interdisciplinary teams with species-specific expertise should collaborate wherever possible and maintain close communication. Mutual openness, cooperation, and willingness to learn form the basis for a fruitful collaboration. Research projects jointly led by or involving both animal and human pathologists make a significant contribution to high-quality biomedical research. Such approaches are promising not only in oncological research, as outlined in this article, but also in other research areas where animal models are regularly used, such as infectiology, neurology, and developmental biology.

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Notes

  1. Aus Gründen der besseren Lesbarkeit wird auf die gleichzeitige Verwendung der Sprachformen männlich, weiblich und divers (m/w/d) verzichtet. Sämtliche Personenbezeichnungen gelten gleichermaßen für alle Geschlechter.

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Wir bedanken uns bei unseren Drittmittelgebern (DFG [SFB1371, SFB1366, TRR187] sowie den N3CRs [Crack-it-Challenge]).

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Authors and Affiliations

  1. Institut für Pathologie und Pathologische Anatomie, School of Medicine and Health, Technische Universität München, Trogerstraße 18, 81675, München, Deutschland

    Tanja Groll, Heike Aupperle-Lellbach, Carolin Mogler &  Katja Steiger

  2. Comparative Experimental Pathology (CEP), School of Medicine and Health, Technische Universität München, München, Deutschland

    Tanja Groll, Heike Aupperle-Lellbach, Carolin Mogler &  Katja Steiger

  3. LABOKLIN GmbH & Co. KG, Bad Kissingen, Deutschland

    Heike Aupperle-Lellbach

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  1. Tanja Groll
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  2. Heike Aupperle-Lellbach
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  3. Carolin Mogler
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  4. Katja Steiger
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Correspondence to Katja Steiger.

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Interessenkonflikt

T. Groll, H. Aupperle-Lellbach, C. Mogler und K. Steiger geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Carolin Mogler, München

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Schwerpunktherausgeberin: Carolin Mogler, München

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Groll, T., Aupperle-Lellbach, H., Mogler, C. et al. Vergleichende Pathologie in der onkologischen Forschung. Pathologie 45, 190–197 (2024). https://doi.org/10.1007/s00292-024-01327-4

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