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Histopathologische Forschungslabors in der translationalen Forschung

Konzeption sowie Integration in die Infrastruktur pathologischer Institute

Histopathological research laboratories in translational research

Conception and integration into the infrastructure of pathological institutes

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Zusammenfassung

Die systematische Auswertung histopathologischer Proben experimenteller Tiersysteme zur Modellierung humaner Erkrankungen stellt heute einen essenziellen Bestandteil hochwertiger biomedizinischer Forschung dar. Leider existieren für diesen erheblichen und zunehmenden Bedarf bisher nur wenige, gezielt ausgebildete Pathologen und kaum etablierte Infrastruktur, sodass sich insbesondere Pathologen an Universitätskliniken zunehmend und im Wesentlichen unvorbereitet mit diesen spezialisierten und zeitraubenden Aufgaben konfrontiert sehen. Dieser Artikel stellt ein neuartiges integriertes Laborkonzept, geführt von Tier- und Humanpathologen an der TU München vor, welches dieses Problem dauerhaft adressieren könnte. Die Laborstruktur wird detailliert mit einem etablierten histopathologischen Routinelabor verglichen und im Hinblick auf Gemeinsamkeiten, Unterschiede, Synergien sowie Vor- und Nachteile beleuchtet.

Abstract

A systematic review of histopathology from experimental animal systems is an essential part of up-to-date biomedical research. Pathologists at university hospitals are especially and increasingly challenged by these specialized and time-consuming duties. This article presents and analyzes a new laboratory structure of comparative experimental pathology—jointly lead by veterinary and human pathologists—which might solve this problem. The focus is on the establishment and full integration of this laboratory structure into a local, regional, and nationwide biomedical research cluster. A detailed comparison with an established structure of routine histopathology laboratories discusses merits and benefits as well as disadvantages.

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Authors and Affiliations

  1. Institut für allgemeine Pathologie und pathologische Anatomie, Technische Universität München, München, Deutschland

    K. Steiger, S. Ballke, H.-Y. Yen, O. Seelbach, A. Alkhamas, M. Boxberg, K. Schwamborn, W. Weichert & C. Mogler

  2. Comparative Experimental Pathology, Technische Universität München, München, Deutschland

    K. Steiger, S. Ballke, H.-Y. Yen, O. Seelbach, A. Alkhamas, M. Boxberg, K. Schwamborn, W. Weichert & C. Mogler

  3. Partnerstandort München, Deutsches Konsortium für Translationale Krebsforschung, München, Deutschland

    H.-Y. Yen, A. Alkhamas & W. Weichert

  4. Institut für Molekulare Immunologie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland

    P. A. Knolle

  5. Vergleichende Experimentelle Pathologie, Institut für Pathologie, Technische Universität München, Trogerstraße 18, 81675, München, Deutschland

    K. Steiger

Authors
  1. K. Steiger
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  2. S. Ballke
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  3. H.-Y. Yen
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  4. O. Seelbach
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  5. A. Alkhamas
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  6. M. Boxberg
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  7. K. Schwamborn
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  8. P. A. Knolle
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  9. W. Weichert
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  10. C. Mogler
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Corresponding author

Correspondence to K. Steiger.

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Interessenkonflikt

K. Steiger, S. Ballke, H.-Y. Yen, O. Seelbach, A. Alkhamas, M. Boxberg, K. Schwamborn, P. A. Knolle, W. Weichert und C. Mogler geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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H.A. Baba, Essen

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Steiger, K., Ballke, S., Yen, HY. et al. Histopathologische Forschungslabors in der translationalen Forschung. Pathologe 40, 172–178 (2019). https://doi.org/10.1007/s00292-018-0458-2

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  • DOI: https://doi.org/10.1007/s00292-018-0458-2

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