Zusammenfassung
Leydig-Zell-, Sertoli-Zell- und Granulosazelltumoren werden nach der WHO-Klassifikation in die Gruppe der Keimstranggonadenstromatumoren eingeteilt. Am häufigsten treten diese Tumoren sporadisch auf, können aber selten mit Syndromen assoziiert sein. Diese Tumorentitäten zeigen charakteristische morphologische Veränderungen, die in Kombination mit immunhistochemischen Markern die Diagnose erleichtern. Neueste molekularpathologische Ergebnisse, insbesondere Mutationsanalysen zu β-Catenin, erlauben zudem eine bessere Kategorisierung dieser Tumorentitäten.
Abstract
According to the World Health Organization (WHO) classification Leydig cell tumors, Sertoli cell tumors and granulosa cell tumors of the testes belong to the group of sex cord-stromal tumors. These tumors most frequently occur sporadically but in rare cases can be associated with syndromes. These tumor entities show characteristic morphological changes, which in combination with specific immunohistochemical markers facilitate the diagnosis. Recent results of molecular pathological investigations, especially beta-catenin mutation analysis, allow a better categorization of these tumor entities.
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F. Bremmer und S. Schweyer geben an, dass kein Interessenkonflikt besteht.
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A. Hartmann, Erlangen
R. Knüchel-Clarke, Aachen
G. Kristiansen, Bonn
Diese Arbeit enthält Passagen des Artikels „Tumoren des Gonadenstromas“, veröffentlicht 2014 in „Der Pathologe“ [2].
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Bremmer, F., Schweyer, S. Leydig-Zell-, Sertoli-Zell- und adulte Granulosazelltumoren. Pathologe 37, 71–77 (2016). https://doi.org/10.1007/s00292-015-0131-y
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DOI: https://doi.org/10.1007/s00292-015-0131-y
Schlüsselwörter
- Leydig-Zell-Tumor
- Sertoli-Zell-Tumor
- Granulosazelltumor
- Morphologische Veränderungen
- β-Catenin-Expression