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Das apokrine Porom

Ein wenig bekannter Hauttumor mit adnexieller Mischdifferenzierung

Apocrine poroma

A relatively little known skin tumor with multilineage differentiation

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Zusammenfassung

Porome wurden ursprünglich in die Gruppe ekkriner Tumoren eingeordnet, die überwiegend aus poroiden duktalen Zellen bestehen, welche in Richtung des Schweißdrüsenausführungsgangs differenzieren. Inzwischen sind jedoch zahlreiche Fälle von Poromen mit zusätzlichen sebozytären und/oder follikulären und/oder apokrin-glandulären Differenzierungsmerkmalen beschrieben und unter dem Begriff des apokrinen Poroms zusammengefasst worden. Die Kombination unterschiedlicher Differenzierungsrichtungen ist durch die embryologisch bedingte Assoziation des Schweißdrüsenausführungsgangs mit anderen Strukturen der sog. follikulo-sebozytären-apokrinen Einheit zu erklären. Die klinischen und histopathologischen Merkmale des apokrinen Poroms werden anhand der Literatur und von 7 eigenen Fällen dargestellt und dem ekkrinen Porom gegenübergestellt. Die Abgrenzung des apokrinen Poroms von einem Sebazeom und von einem Basalzellkarzinom mit sebozytärer Differenzierung ist von Bedeutung, da die Diagnosen therapeutische Konsequenzen für den Patienten haben. Daher wird zusätzlich auf die histopathologische Unterscheidung des apokrinen Poroms von diesen Tumoren eingegangen.

Abstract

Poromas were originally classified as eccrine tumors which predominantly consist of poroid ductal cells and differentiate in the direction of sweat gland ducts. However, there have now been many reports on poromas with additional differential characteristics differentiating in the direction of sebaceous and/or apocrine glands and/or hair follicles. These tumors have been termed apocrine poromas. Multilineage differentiation within a poroma can be explained by the embryological association of the sweat duct with the so-called folliculo-sebaceous-apocrine unit. The clinical and histopathological features of apocrine poromas are reviewed in comparison to classical eccrine poromas by taking into account seven own cases of apocrine poroma and a review of the literature. It is important for histopathologists not to confuse apocrine poroma with other tumors with multilineage differentiation. Apocrine poroma needs to be distinguished from sebaceoma and from basal cell carcinoma with sebaceous differentiation, in particular, because these tumors have therapeutic consequences for the patient. The main histopathological differences between apocrine poroma, sebaceoma and basal cell carcinoma with sebaceous differentiation are explained.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. K. Flux und F. Eggert geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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  1. Labor für Dermatohistologie und Oralpathologie, Bayerstr. 69, 80335, München, Deutschland

    K. Flux M.D. & F. Eckert

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  1. K. Flux M.D.
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  2. F. Eckert
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Correspondence to K. Flux M.D..

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Flux, K., Eckert, F. Das apokrine Porom. Pathologe 35, 456–461 (2014). https://doi.org/10.1007/s00292-014-1931-1

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