Skip to main content
SpringerLink
Log in

Hautadnex- vs. Speicheldrüsentumoren

Analoges und Divergentes

Cutaneous adnexal and salivary gland tumours

Similarities and differences

  • Schwerpunkt
  • Published:
Der Pathologe Aims and scope Submit manuscript

Zusammenfassung

Trotz gravierender Unterschiede in der zugrunde liegenden mikroskopischen Anatomie bestehen innerhalb des weiten Spektrums von Hautadnex- und Speicheldrüsentumoren bemerkenswerte Ähnlichkeiten. In der vorliegenden Arbeit werden Typen von Speicheldrüsen- und Hautadnextumoren mit histologischen, terminologischen und pathogenetischen Analogien identifiziert und verglichen. Histologische Analogien von Speicheldrüsentumoren beziehen sich auf ekkrine, apokrine und selten sebozytäre (nicht trichofollikuläre) Typen von Hautadnextumoren. Die auffälligste Analogie besteht zwischen dem pleomorphen Adenom der Speicheldrüsen und dem kutanen Mischtumor. Eine Mehrschrittkanzerogenese, beginnend mit einem intraduktalen Karzinom, welche beim Karzinom ex pleomorphes Adenom identifiziert wurde, ist identisch manifest beim kutanen Karzinom ex Spiradenom. Weitere histologische und/oder terminologische Analogien werden aufgezeigt für muzinöse/mukoepidermoide Karzinome, Lymphadenome/lymphoepitheliale Karzinome, sebazeöse Adenome bzw. Karzinome, adenoidzystische Karzinome sowie für Basalzelladenome der Speicheldrüsen vs. kutane Spiradenome. Manifeste diagnostische Probleme bzgl. histologisch ähnlicher Speicheldrüsen- und Hautadnextumoren sind selten und topographisch beschränkt auf die parotideale und orale Region.

Abstract

Despite major discrepancies in basic microscopic anatomy, remarkable similarities are manifest within the wide spectrum of cutaneous adnexal and salivary gland tumors. In this study salivary gland and adnexal tumors were identified and investigated with respect to similarities in histology, terminology and pathogenesis. Histological similarities of certain types of salivary gland tumors relate to eccrine, apocrine and rarely sebaceous (but not trichofollicular) types of adnexal tumors. The most striking similarity was found with salivary gland pleomorphic adenoma and cutaneous mixed tumor. Multistep carcinogenesis starting with intraductal carcinoma, identified in carcinoma ex pleomorphic adenoma is identical to that found in cutaneous carcinoma ex spiradenoma. Further histological and terminological similarities are shown for mucinous and mucoepidermoid carcinoma, for lymphadenoma and lymphoepithelial carcinoma, for sebaceous adenoma and carcinoma, for adenoid-cystic carcinoma, as well as for salivary gland basal cell adenoma versus cutaneous spiradenoma. Manifest diagnostic problems related to histologically similar salivary gland and adnexal tumors are rare and are topographically limited to the parotid and oral areas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Bahrami A, Dalton JD, Krane JF et al (2012) A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart. Genes Chromosomes Cancer 51:140–148

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Eckert F, Betke M, Schmoeckel C et al (1992) Myoepithelial differentiation in benign sweat gland tumors. Demonstrated by a monoclonal antibody to alpha-smooth muscle actin. J Cutan Pathol 19:294–301

    Article  CAS  PubMed  Google Scholar 

  3. Eckert F, Pfau A, Landthaler M (1994) Adenoid cystic sweat gland carcinoma. A clinicopathologic and immunohistochemical study. Hautarzt 45:318–323

    Article  CAS  PubMed  Google Scholar 

  4. Eckert F, Schmid U, Hardmeier T et al (1992) Cytokeratin expression in mucinous sweat gland carcinomas: an immunohistochemical analysis of four cases. Histopathology 21:161–165

    Article  CAS  PubMed  Google Scholar 

  5. Ferlicot S, Plantier F, Rethers L et al (2000) Lymphoepithelioma-like carcinoma of the skin: a report of 3 Epstein-Barr virus (EBV)-negative additional cases. Immunohistochemical study of the stroma reaction. J Cutan Pathol 27:306–311

    Article  CAS  PubMed  Google Scholar 

  6. Flucke U, Palmedo G, Blankenhorn N et al (2011) EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases. Mod Pathol 24:1444–1450

    Article  CAS  PubMed  Google Scholar 

  7. Ihrler S, Schwarz S, Zengel P et al (2009) Pleomorphic adenoma: pitfalls and clinicopathological forms of progression. Pathologe 30:446–456

    Article  CAS  PubMed  Google Scholar 

  8. Ihrler S, Weiler C, Hirschmann A et al (2007) Intraductal carcinoma is the precursor of carcinoma ex pleomorphic adenoma and is often associated with dysfunctional p53. Histopathology 51:362–371

    Article  CAS  PubMed  Google Scholar 

  9. Ihrler S, Zietz C, Sendelhofert A et al (2002) A morphogenetic concept of salivary duct regeneration and metaplasia. Virchows Arch 440:519–526

    Article  PubMed  Google Scholar 

  10. Ivan D, Nash JW, Prieto VG et al (2007) Use of p63 expression in distinguishing primary and metastatic cutaneous adnexal neoplasms from metastatic adenocarcinoma to skin. J Cutan Pathol 34:474–480

    Article  PubMed  Google Scholar 

  11. Kazakov DV, Banik M, Kacerovska D et al (2011) A cutaneous adnexal neoplasm with features of adamantinoid trichoblastoma (lymphadenoma) in the benign component and lymphoepithelial-like carcinoma in the malignant component: a possible case of malignant transformation of a rare trichoblastoma variant. Am J Dermatopathol 33:729–732

    Article  PubMed  Google Scholar 

  12. Kazakov DV, Belousova IE, Bisceglia M et al (2007) Apocrine mixed tumor of the skin („mixed tumor of the folliculosebaceous-apocrine complex“). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases. J Am Acad Dermatol 57:467–483

    Article  PubMed  Google Scholar 

  13. Kazakov DV, Kacerovska D, Hantschke M et al (2011) Cutaneous mixed tumor, eccrine variant: a clinicopathologic and immunohistochemical study of 50 cases, with emphasis on unusual histopathologic features. Am J Dermatopathol 33:557–568

    Article  PubMed  Google Scholar 

  14. Kazakov DV, Magro G, Kutzner H et al (2008) Spiradenoma and spiradenocylindroma with an adenomatous or atypical adenomatous component: a clinicopathological study of 6 cases. Am J Dermatopathol 30:436–441

    Article  PubMed  Google Scholar 

  15. Kazakov DV, Suster S, Leboit PE et al (2005) Mucinous carcinoma of the skin, primary, and secondary: a clinicopathologic study of 63 cases with emphasis on the morphologic spectrum of primary cutaneous forms: homologies with mucinous lesions in the breast. Am J Surg Pathol 29:764–782

    Article  PubMed  Google Scholar 

  16. Kazakov DV, Zelger B, Rutten A et al (2009) Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol 33:705–719

    Article  PubMed  Google Scholar 

  17. Lehmer LM, Ragsdale BD, Crawford RI et al (2012) Mucoepidermoid carcinoma of the parotid presenting as periauricular cystic nodules: a series of four cases. J Cutan Pathol 39:712–717

    Article  PubMed  Google Scholar 

  18. Mentzel T (2004) Skin adnexal and salivary gland neoplasms. Similarities and differences of selected patients. Pathologe 25:79–88

    Article  CAS  PubMed  Google Scholar 

  19. Mentzel T, Requena L, Kaddu S et al (2003) Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. J Cutan Pathol 30:294–302

    Article  PubMed  Google Scholar 

  20. Obaidat NA, Alsaad KO, Ghazarian D (2007) Skin adnexal neoplasms – part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol 60:145–159

    Article  PubMed Central  PubMed  Google Scholar 

  21. Rütten A, Kutzner H, Hügel H (1994) Das adenoidzystische Karzinom der Haut. Akt Dermatol 20:119–121

    Google Scholar 

  22. Schneider M, Rizzardi C (2008) Lymphoepithelial carcinoma of the parotid glands and its relationship with benign lymphoepithelial lesions. Arch Pathol Lab Med 132:278–282

    PubMed  Google Scholar 

  23. Scholz IM, Hartschuh W (2010) Primary mucinous eccrine carcinoma of the skin – a rare clinical tumor with many differential diagnoses. J Dtsch Dermatol Ges 8:446–448

    Article  PubMed  Google Scholar 

  24. Schwartz RA, Wiederkehr M, Lambert WC (2004) Secondary mucinous carcinoma of the skin: metastatic breast cancer. Dermatol Surg 30:234–235

    PubMed  Google Scholar 

  25. Seethala RR, Thompson LD, Gnepp DR et al (2012) Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol 25:26–35

    Article  PubMed  Google Scholar 

  26. Wach F, Hein R, Kuhn A et al (1994) Immunohistochemical demonstration of myoepithelial cells in sweat gland carcinomas. Br J Dermatol 130:432–437

    Article  CAS  PubMed  Google Scholar 

  27. Weiler C, Agaimy A, Zengel P et al (2012) Nonsebaceous lymphadenoma of salivary glands: proposed development from intraparotid lymph nodes and risk of misdiagnosis. Virchows Arch 460:467–472

    Article  PubMed  Google Scholar 

  28. Weiler C, Zengel P, Van Der Wal JE et al (2011) Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation of 41 cases. Histopathology 59:741–750

    Article  PubMed  Google Scholar 

  29. Welch PQ, Williams SB, Foss RD et al (2011) Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:78–86

    Article  PubMed  Google Scholar 

  30. Wick MR, Ockner DM, Mills SE et al (1998) Homologous carcinomas of the breasts, skin, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma. Am J Clin Pathol 109:75–84

    CAS  PubMed  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. S. Ihrler, C. Weiler, F. Eckert, M. Mollenhauer geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Labor für Dermatohistologie und Oralpathologie, Bayerstr. 69, 80335, München, Deutschland

    S. Ihrler & F. Eckert

  2. Pathologisches Institut, Ludwig-Maximilians-Universität, München, Deutschland

    S. Ihrler

  3. Praxis für Pathologie, Karl-Olga-Krankenhaus, Stuttgart, Deutschland

    C. Weiler

  4. Institut für Pathologie, Technische Universität, München, Deutschland

    M. Mollenhauer

Authors
  1. S. Ihrler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Weiler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Eckert
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Mollenhauer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Ihrler.

Additional information

Auszüge dieser Arbeit wurden 2014 bei den 15. Bamberger Morphologietagen vorgetragen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ihrler, S., Weiler, C., Eckert, F. et al. Hautadnex- vs. Speicheldrüsentumoren. Pathologe 35, 476–486 (2014). https://doi.org/10.1007/s00292-014-1929-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00292-014-1929-8

Schlüsselwörter

Keywords

Search

Navigation