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Biodegradable microfibrous, electrospunned hydroxyapatite nanoparticles/poly(glycerol sebacate)-co-poly(ε-caprolactone) nanocomposite scaffolds for tissue engineering applications

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Abstract

Soft tissue engineering has focused on green, solvent-free biopolymers with rubber-like characteristics. One of the well-known elastomeric polyesters is polyglycerol sebacate (PGS). The present investigation involves the synthesis of a novel biopolymer composed of PGS-co-poly(ε-caprolactone) (PCL) copolymer, alongside hydroxyapatite (HA) using bovine bone. These synthesized materials were utilized to build scaffolds using 18–22 kV electrospinning. By in situ polymerization, PGS-co-PCL/HA nanocomposites with 5% and 10% hydroxyapatite nanoparticles were developed. Various analysis such as FTIR, TGA, SEM, and DSC were utilized to examine the prepared samples. Introducing 10% HA to the PGS-co-PCL copolymer blends boosted nanocomposite mechanical strength by 300%. Meanwhile, PGS-co-PCL-based samples and their nanocomposites demonstrated promising biocompatibility and antibacterial characteristics. Biodegradability experiments revealed that at pH 7, PGS-co-PCL-HA10% was degraded by 45% within 30 days, whereas at pH 11, degradation accelerated to 65%. This study’s findings provide a novel approach for soft tissue engineers to construct effective scaffolds with great biocompatibility and enhanced mechanical properties by combining PGS with co-PCL and adding HA nanoparticles.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Advanced Materials Research Center, Materials Engineering Department, Najafabad Branch, Islamic Azad University, Najafabad, Iran

    Tahere Pourhoseyini & Farid Naeimi

  2. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mehdi Mehrazin

  3. Department of Processing, Iran Polymer and Petrochemical Institute, PO Box 14965/115, Tehran, Iran

    Mozhdeh Madadi & Hossein Ali Khonakdar

Authors
  1. Tahere Pourhoseyini
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  2. Farid Naeimi
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  3. Mehdi Mehrazin
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Correspondence to Farid Naeimi or Hossein Ali Khonakdar.

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Pourhoseyini, T., Naeimi, F., Mehrazin, M. et al. Biodegradable microfibrous, electrospunned hydroxyapatite nanoparticles/poly(glycerol sebacate)-co-poly(ε-caprolactone) nanocomposite scaffolds for tissue engineering applications. Polym. Bull. (2024). https://doi.org/10.1007/s00289-024-05235-8

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  • DOI: https://doi.org/10.1007/s00289-024-05235-8

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