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Development of ciprofloxacin-loaded polymeric nanoparticles for drug delivery

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Studies in which polymeric nanoparticles are used in drug delivery have been one of the subjects of interest in recent years. In this study, histidine-containing polymeric nanoparticles [poly(2-hydroxyethyl methacrylate-co-N-methacryloylamido histidine methyl ester)] were synthesized by surfactant free emulsion polymerization method. Ciprofloxacin was loaded onto the HPCNs surface [CIP-HCPNs]. In the characterization of CIP-HCPNs, scanning electron microscopy, Fourier-infrared analysis, surface area calculations and zeta potential analysis were used. FT-IR data of histidine-free polymeric nanoparticles [HFPNs] and HCPNs demonstrated the successful addition of Histidine to polymeric nanoparticles. SEM images showed that CIP-HCPNs had a size of 131.2 nm with a spherical shape. As a result of Zeta potential studies, the polydispersity index (PDI) of CIP-HCPNs was found to be 0.11, indicating that CIP-HCPNs have a narrowly spaced size distribution. CIP release from CIP-HCNPs showed slow-release properties. At pH 7.4, cumulative CIP release from CIP-HCPNs was 96% (283.35 mg/g) within 6 h, with full drug release achieved at 24 h. It was stated that the drug release kinetic data obtained from CIP release experiments fit the Hixson-Crowell model, and in this model, CIP release from CIP-HCPNs occurred as the square root of the time dependent process based on Fickian diffusion. As a result, CIP-HCNPs developed in the current study, it can be said that it is suitable for drug release.

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Acknowledgements

Authors would like to thank Canser Kuşat Lanpir for drawing the images in the manuscript.

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Authors and Affiliations

  1. Turkey Drug and Medical Devices Agency, Ankara, Turkey

    Kevser Kuşat

  2. Department of Biochemistry, Faculty of Science, Ege University, İzmir, Turkey

    Sinan Akgöl

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Kuşat, K., Akgöl, S. Development of ciprofloxacin-loaded polymeric nanoparticles for drug delivery. Polym. Bull. 81, 6555–6569 (2024). https://doi.org/10.1007/s00289-023-05021-y

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