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Pectin nanoforms—a multifaceted polysaccharide and a propitious nanocarrier for medical ailments

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Abstract

Pectin is a natural anionic hetero-polysaccharide substantially found in fruits and cell wall of plants. Nanomaterials of natural polysaccharides are the excellent carriers for targeting specific drug delivery due to multivalent interaction of sugar molecules. Pectin-based nanoforms manifest good stability, safety, low immunogenicity, low toxicity, hydrophilicity, gelling ability and biodegradability, which propose their applicability in various biomedical application. Pectin-based nanoparticles can inhibit the growth of several pathogenic bacteria including Staphylococcus aureus, Escherichia coli and Aspergillus japonicus. In addition, it also exhibits strong antioxidant property which can scavenge free radicals and help to prevent or manage various disease conditions. Its role in the detoxification of metals and carcinogens as well as its anti-carcinogenic qualities have made it of great interest to cancer researchers. The pectin-based nanocarrier offer a promising platform for the delivery of a wide range of drugs including chemotherapeutic drugs with good pharmacokinetics and controlled drug release. This review describes the neoteric evidence of pectin and their nano-formulations in biomedical applications as an antimicrobial, antioxidant, anticancer agents and a key role in drug delivery mechanisms.

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Pectin based metal nanoparticles and its biomedical applications

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  1. Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed-to-be-University), JC Road, Sudhama Nagar, Bangalore, 560027, Karnataka, India

    Vaishnavi Shashidhara & Madhavarani Alwarsamy

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Shashidhara, V., Alwarsamy, M. Pectin nanoforms—a multifaceted polysaccharide and a propitious nanocarrier for medical ailments. Polym. Bull. 81, 4801–4818 (2024). https://doi.org/10.1007/s00289-023-04972-6

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