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Preparation of alginate magnetic nanoparticles based on Fe3O4 as anticancer drug delivery vehicle: imatinib loading and in vitro release study

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Abstract

In this study, a novel nanocarrier based on magnetic nanoparticles was synthesized via a facile method and modified by alginate. The synthesized nanocarrier was characterized using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis, Brunauer–Emmett–Teller, vibrating sample magnetometer, and x-ray diffraction analysis. Different factors were optimized to evaluate the adsorption of imatinib on the nanoadsorbent. Imatinib was chosen as an anti-cancer drug, and the release rate of imatinib was investigated in simulated human blood (pH = 7.4) and simulated cancer (pH = 5.6) fluids. The drug adsorption isotherms, kinetics, and thermodynamics were studied. Based on the equilibrium adsorption results, the Langmuir isotherm and the pseudo-second-order kinetic models indicated a better fit than other models. Values of the enthalpy and entropy for drug sorption on the nanoadsorbent were positive. The negative value of Gibbs free energy reveals the spontaneous and feasible adsorption of imatinib on the nanoadsorbent.

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Acknowledgements

The authors would like to acknowledge Islamic Azad University (Science and Research branch) for financial support of this project.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Shirin Kalani & Seyed Abolhassan Alavi

  2. Department of Chemistry, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran

    Elham Moniri

  3. Department of Biochemistry and Biophysics, Varamin (Pishva) Branch, Islamic Azad University, Varamin, Iran

    Raheleh Safaeijavan

Authors
  1. Shirin Kalani
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  2. Elham Moniri
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  3. Seyed Abolhassan Alavi
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  4. Raheleh Safaeijavan
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Contributions

SK contributed to methodology, conceptualization, investigation, formal analysis, validation, writing—original draft. EM contributed to supervision, project administration, formal analysis, validation, writing—original draft. AA contributed to supervision, project administration, formal analysis, validation, writing—original draft. RS contributed to project administration, formal analysis, writing—review and editing, and investigation.

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Correspondence to Elham Moniri.

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Kalani, S., Moniri, E., Alavi, S. et al. Preparation of alginate magnetic nanoparticles based on Fe3O4 as anticancer drug delivery vehicle: imatinib loading and in vitro release study. Polym. Bull. 81, 1229–1248 (2024). https://doi.org/10.1007/s00289-023-04760-2

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  • DOI: https://doi.org/10.1007/s00289-023-04760-2

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