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Drug delivery system in bone biology: an evolving platform for bone regeneration and bone infection management

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Abstract

Human osteology is the biomechanics science that deals with the study of minerals and non-collagenous organic components that shield human organs and aids in the production of blood cells. A bone follows a specific regenerative pattern after injury or defect. Direct healing ability is still a substantial medical challenge in pathological or nonunion conditions. Such bone defects often necessitate a choice of biomaterial matrix (polymer/ceramic/bioglasses/metallic implants) with the combinations of bioactive signaling molecules (drug molecules) in a spatiotemporal pattern. In this regard, we address the development of a drug delivery system and also outline the interactions of drug molecules with the scaffolding surface that could further trigger the regeneration process. Eventually, the review highlights the notion of drug embedded onto the three-dimensional scaffolds and the release profiles surface coated metallic implant that creates a new window for bone tissue engineering. Besides, a systematic review was performed for literature regarding the role of antibiotics and dual drug delivery strategies that would have a potential utilization of bone-related infection control.

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Acknowledgements

The authors thank VIT University, Vellore, for providing all required facilities, and also one of the authors Dr. U. Vijayalakshmi highly acknowledges DST, New Delhi, India, (EMR/2016/002562) for financial support. Another author, M. Rama thank Indian Council of Medical Research for the award of Senior Research Fellowship (45/39/2020-/BIO/BMS) for Financial assistance.

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  1. Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, India

    M. Rama & U. Vijayalakshmi

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  1. M. Rama
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  2. U. Vijayalakshmi
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Correspondence to U. Vijayalakshmi.

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Rama, M., Vijayalakshmi, U. Drug delivery system in bone biology: an evolving platform for bone regeneration and bone infection management. Polym. Bull. 80, 7341–7388 (2023). https://doi.org/10.1007/s00289-022-04442-5

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