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Anticancer and antimicrobial evaluation of novel conductive ZnO2 doped polymer patches for cancer treatment and tissue engineering applications

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Abstract

The novel polymer composites POT + PCL, POT + ZnO2/PCL were prepared as patches by solution casting technique. The synthesized patches characterized by XRD, FT-IR and FESEM analysis. Besides, the samples were subjected to DC conductivity study and biological activities. The POT + ZnO2/PCL composites have higher conductivity in the conducting range 0.04 × 10–2 (S/cm) compared to POT + PCL film. Antibacterial activity was tested on the composites against gramme positive (S. aureus) and gramme negative (E. coli) bacterial pathogens. At high dosages, both patches demonstrated substantial antibacterial action against E. coli. Furthermore, in vitro anticancer studies on MG63 bone cancer cells demonstrated that POT + ZnO2/PCL composites had the maximum cytotoxicity (27.33 μg/ml), followed by POT + PCL (44.93 μg/ml) composite patch. Overall, the results of this investigation revealed significant electrical characteristics, antibacterial activity, and anticancer activity, suggesting that they could be applied in scaffolds for tissue engineering, anticancer therapy, as well as other applications in biomedicine.

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Authors and Affiliations

  1. Department of Physics, KPR Institute of Engineering and Technology, Coimbatore, Tamil Nadu, 641 407, India

    V. Gayathri

  2. Department of Physics, Chikkanna Government Arts College, Tirupur, Tamil Nadu, 641 602, India

    R. Balan & V. Gayathri

  3. Department of Physics, Info Institute of Engineering, Coimbatore, Tamil Nadu, India

    R. Priya

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Balan, R., Gayathri, V. & Priya, R. Anticancer and antimicrobial evaluation of novel conductive ZnO2 doped polymer patches for cancer treatment and tissue engineering applications. Polym. Bull. 79, 10625–10638 (2022). https://doi.org/10.1007/s00289-021-04001-4

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