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New glyco-copolymers containing α-D-glucofuranose and α-D-mannofuranose groups synthesized by free-radical polymerization of sugar-based monomers

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Abstract

Carbohydrates are safe materials with the potential of application in various areas, hence, in recent years, a growing interest has been attracted to the synthesis of the new systems containing carbohydrates. By considering this and based on the carbohydrate's merits, in this work, the new two different random glyco-copolymers were prepared through the polymerization of the α-D-glucofuranose- and α-D-mannofuranose-based monomers. A facile free-radical polymerization technique was utilized for glyco-copolymers synthesis in the presence of benzoyl peroxide (BPO) as an initiator. Fourier transform infrared (FT-IR) technique was used for investigating the achievements in the synthesis of copolymers. In the proton nuclear magnetic resonance (1H NMR) spectroscopy analysis, the absence of any peaks in the rigon related to vinylic protons confirmed the successful synthesizing of glyco-copolymers. As well as, enhancing the intensity of the peaks in the 0.60–2.39 ppm which is related to the formed aliphatic protons as a result of vinylic glycomonomers copolymerization is the strong witness for success in copolymerization. In this way and by considering the special structure of the prepared glyco-copolymers and based on the review of the published literature, it is expected that the prepared new glyco-copolymers be a good candidate for biomedicinal applications.

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Acknowledgements

Authors gratefully acknowledge the University of Tabriz and Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science for the financial supports for this research.

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Authors and Affiliations

  1. Research Laboratory of Dendrimers and Nano-Biopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 5166616471, Tabriz, Iran

    Hassan Namazi, Malihe Pooresmaeil & Maryam Nasiri Oskooie

  2. Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science, Tabriz, Iran

    Hassan Namazi

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  1. Hassan Namazi
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Namazi, H., Pooresmaeil, M. & Oskooie, M.N. New glyco-copolymers containing α-D-glucofuranose and α-D-mannofuranose groups synthesized by free-radical polymerization of sugar-based monomers. Polym. Bull. 79, 4891–4903 (2022). https://doi.org/10.1007/s00289-021-03731-9

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