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Preparation and characterization of gelatin base cross-linking aerogel and nanoclay aerogel for diltiazem drug delivery

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Abstract

In this investigation, we decided to prepare efficient aerogel for loading and releasing drug in vitro situation. Here we introduced the synthesis of gelatin-based cross-linking poly vinyl acetate/acrylic acid aerogel and nanoclay aerogel, which synthesized by free radical condition and called gelatin-g-VA–AA (A) and gelating-VA–AA/MMT (B), respectively, and they were used them for drug delivery of diltiazem. The synthesized aerogels were completely identified by FTIR, TGA, DTG, SEM, TEM, XRD that showed nanocomposites size with about 40–70 nm, highly uniform porous surface and with high temperature stability. In addition, drug delivery activities of aerogels were tested in saline solution, temperature, the percentage of nanoclay and time effect. Moreover, pH sensitivity of aerogels was investigated for characterization of drug loading and drug releasing amounts at different pHs, distilled water and buffers to determine the best condition for each situation which results illustrated the universal buffer at pH 5 and 7 for drug loading and pH 7 and 10 for drug releasing had the least interaction with aerogels and nano-aerogel, respectively.

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Acknowledgements

The authors extend their appreciation to the Azad University of Arak-Iran for financial support of this work.

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  1. Department of Chemistry, Arak Branch, Islamic Azad University, P.O. Box 38135-567, Arak, Iran

    Amir Hajikarimi & Mohammad Sadeghi

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  1. Amir Hajikarimi
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Correspondence to Mohammad Sadeghi.

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Hajikarimi, A., Sadeghi, M. Preparation and characterization of gelatin base cross-linking aerogel and nanoclay aerogel for diltiazem drug delivery. Polym. Bull. 79, 3987–4011 (2022). https://doi.org/10.1007/s00289-021-03696-9

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