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Synthesis of graft copolymers of carboxymethyl cellulose and N,N-dimethylaminoethyl methacrylate and their study as Paclitaxel carriers

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Abstract

The double-sensitive graft copolymers of sodium salt of carboxymethyl cellulose (Na-CMC) and N,N-dimethylaminoethyl methacrylate (DMAEMA) with different content are successfully synthesized by radical polymerization applying a redox initiator. Aqueous solution of the synthesized copolymers has a lower critical solution temperature (LCST) in the range of 37–44 °C, and the sizes of copolymer particles being multichain spherical negative-charged aggregates are in a 118–133 nm range. Na-CMC-g-PDMAEMA copolymer particles are stable in a 0.15 N NaCl aqueous solution and in the physiological pH range, which allows to apply them as vectors for targeted drug delivery. Conjugation between Paclitaxel (Ptx) and Na-CMC-g-PDMAEMA copolymer is due to hydrophobic and electrostatic interaction between functional groups of each component; copolymers are characterized by relatively high values of loading and encapsulation efficiencies of Ptx. In vitro release kinetics was also researched in acidic and neutral media at 38 °C. The release process of Ptx from a copolymer conjugate is described by Korsmeyer–Peppas kinetic model and limited by molecular diffusion.

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Acknowledgements

FTIR, TEM, UV spectroscopy, zeta-potential data were obtained with the use of equipment of Centre of collective usage of scientific equipment of Voronezh State University.

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Authors and Affiliations

  1. Polymer Science and Colloid Chemistry Department, Voronezh State University, Voronezh, 394018, Russia

    Andrey V. Sorokin & Vyacheslav A. Kuznetsov

  2. Molecular Biotechnology Department, Voronezh State University, Voronezh, 394018, Russia

    Maria S. Lavlinskaya

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  1. Andrey V. Sorokin
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  2. Vyacheslav A. Kuznetsov
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Correspondence to Andrey V. Sorokin.

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Sorokin, A.V., Kuznetsov, V.A. & Lavlinskaya, M.S. Synthesis of graft copolymers of carboxymethyl cellulose and N,N-dimethylaminoethyl methacrylate and their study as Paclitaxel carriers. Polym. Bull. 78, 2975–2992 (2021). https://doi.org/10.1007/s00289-020-03250-z

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