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Synthesis and characterization of radiation cross-linked PVP hydrogels and investigation of its potential as an antileishmanial drug carrier

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Abstract

The aim of this study was to elaborate a suitable hydrogel to be used as drug carrier for antileishmanial treatment. Therefore, a PVP hydrogel was synthesized using gamma radiation technique. In the first step, PVP, agar and PEG concentrations were modified as a function of dose rate. Then, established polymers were characterized using FTIR, solid-state 13C NMR and TGA analyses. After that, rheological measurements followed to determine elastic and viscous modulus. Based on these techniques, it was found that synthesized PVP–hydrogels have the structure of a semi-interpenetrated network (SIPN). The sample containing 3% of PEG was selected to test its potential as antileishmanial drug carrier because it had the elastic modulus that fits more the application as wound dressing. As antileishmanial drug carrier, it has been shown that in the presence of hydrogel, the activity of conventional drug (Amphotericin B) on Leishmania promastigotes was markedly improved with an increase in selectivity index from 10.54 to 56.8.

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Acknowledgements

Biological tests of the hydrogel were carried out in the Laboratory of Bioactive Substances at the Center of Biotechnology of Borj Cedria of Tunisia, under the responsibility of Professor Ferid Limam to whom we are grateful.

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Authors and Affiliations

  1. Laboratory of Useful Materials Valuation, National Center for Research in Materials Sciences, Borj Cedria Technopark, BP 73, 8027, Soliman, Tunisia

    Nour Elhouda Ben Ammar & Ahmed Hichem Hamzaoui

  2. Laboratory of Bioactive Substances, Biotechnology Center of Borj-Cedria Technopole, BP 901, 2050, Hammam-Lif, Tunisia

    Rym Essid & Salem Elkahoui

  3. Laboratory of Analytical Chemistry and Electrochemistry, Sciences Faculty of Tunis, University of Tunis El-Manar, University Campus, 2092, Tunis, Tunisia

    Taieb Saied

  4. Polymer Chemistry Division, Department of Chemistry, Hacettepe University, 06800, Beytepe Ankara, Turkey

    Murat Şen

  5. Institute of Science, Polymer Science and Technology Division, Hacettepe University, 06800, Beytepe, Ankara, Turkey

    Murat Şen

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  1. Nour Elhouda Ben Ammar
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  6. Ahmed Hichem Hamzaoui
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Ben Ammar, N.E., Essid, R., Saied, T. et al. Synthesis and characterization of radiation cross-linked PVP hydrogels and investigation of its potential as an antileishmanial drug carrier. Polym. Bull. 77, 1343–1357 (2020). https://doi.org/10.1007/s00289-019-02803-1

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