Abstract
In the present investigation, synthesis of silver nanoparticles (AgNPs) has been successfully carried out in a very simple and cost-effective manner by reducing Ag+ ions in sodium alginate solution and further stabilizing the colloidal mixture with gelatin solution. The ultraviolet–visible (UV–vis) spectra were in excellent agreement with the nanostructure morphology obtained from dynamic light scattering transmission electron microscopy and their size distributions. Increase in precursor concentration was found to promote agglomeration of AgNPs. Antibacterial assays revealed that the nanoformulations were more active against Gram-negative bacteria. Swelling studies of the hydrogel films demonstrated a rapid increase in water uptake. However, an increase in swelling % was observed with decreasing AgNP content. The use of biocompatible materials such as sodium alginate and gelatin not only provides green and economic attributes to this piece of research work but, at the same time, also opens up possibilities of using the nanoformulations in wound dressings, active packaging and several other biomedical applications.
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Acknowledgments
PKB and AS are thankful to Department of Biotechnology, New Delhi for financing the project under the DBT-MSUB Programme (BT/PR4800/INF/22/152/2012 dated 22/03/2012). CA and CRP are thankful to Director, Institute of Minerals and Materials Technology (CSIR-IMMT), Bhubaneswar, Odisha for providing necessary facilities to carry out the present work. The authors are also thankful to Dr. S. Vivekanandhan, VHNSN College, Tamil Nadu, India for his valuable suggestions during preparation of the manuscript.
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Acharya, C., Panda, C.R., Bhaskara, P.K. et al. Physicochemical and antimicrobial properties of sodium alginate/gelatin-based silver nanoformulations. Polym. Bull. 74, 689–706 (2017). https://doi.org/10.1007/s00289-016-1738-8
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DOI: https://doi.org/10.1007/s00289-016-1738-8